Evidence map›Paper›PMID 41890732›Full record

ArticleFrontiers in immunology2026

METTL3-driven m

Mingzhi Xu, Ruman Chen, Xin Zeng, Mingjiao Pan, Chunli Wang, Yonghui Qi, Na An, Yafei Bai

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. RNA mActa pharmacologica Sinica · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingzhi XuBlood Purification Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Ruman ChenBlood Purification Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Xin ZengBlood Purification Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Mingjiao PanBlood Purification Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Chunli WangBlood Purification Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Yonghui QiBlood Purification Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Na AnBlood Purification Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Yafei BaiBlood Purification Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: METTL3-mediated m Methods: An Results: TGF-β1 upregulated METTL3, NLRC5, and global m Conclusions: METTL3 promotes renal fibrosis by stabilizing NLRC5 mRNA via m

Indexed as

Intracellular Signaling Peptides and ProteinsKelch-Like ECH-Associated Protein 1KidneyMethyltransferasesNF-E2-Related Factor 2Renal Insufficiency, ChronicAnimalsAntioxidant Response ElementsCell LineDisease Models, AnimalFibrosisHumansMaleMiceMice, Inbred C57BLRNA MethylationIntracellular Signaling Peptides and ProteinsKEAP1 protein, humanKeap1 protein, mouseKelch-Like ECH-Associated Protein 1MethyltransferasesMETTL3 protein, humanMettl3 protein, mouseNFE2L2 protein, humanNF-E2-Related Factor 2NLRC5 protein, humanNLRC5 protein, mouseKeap1/Nrf2/ARE pathwayM6A RNA methylationMETTL3NLRC5renal fibrosis

Identifiers

PMID41890732
PMCPMC13014212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.