ReviewiScience2026
Biomechanical regulation of stem cells: Implications for cell therapeutics.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell biology has rapidly expanded into an interdisciplinary field with potential for next-generation cell-based therapies. However, a critical gap remains in our understanding of how physical forces influence stem cell behavior. Recent studies in mechanotransduction, the process by which cells sense and convert mechanical cues into biochemical signals, have revealed that biomechanical regulation is fundamental for stem cell fate, proliferation, and therapeutic efficacy. This review synthesizes recent findings on the intrinsic and extrinsic parameters of physical cues that govern mechanotransduction and shape stem cell biology, highlights the mechanosensitive responses, and explores how biomedical engineering (BME) can be employed to manipulate these processes to improve translational outcomes in clinical settings. By integrating insights from cell biology, mechanobiology, and engineering, this interdisciplinary field offers strategies to translate benchside discoveries into clinical applications, advancing the development of precise and effective stem cell-based therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.