Direct RNA Sequencing Reveals Stress-Dependent and Pathway-Specific rRNA Modification Reprogramming during 50S Biogenesis.

Luis A Gracia Mazuca, Salvador Rodarte, Isaac S Weislow, Jonathon E Mohl, Eda Koculi

Abstract read

In one paragraph

Article in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Selective Reprogramming of Ribosome Assembly and Translational Control during Bacterial Growth Phase Transitions.ACS omega · 2026
Article

4 · The record

Corrections and comments

Update of
Direct RNA Sequencing Reveals Stress-Dependent and Pathway-Specific rRNA Modification Reprogramming During 50S Biogenesis.2026

5 · Who and what money

Authors and funding

5 authors.

Luis A Gracia MazucaDepartment of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.ORCID 0009-0007-1334-7758

Salvador RodarteComputational Sciences Program, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Isaac S WeislowDepartment of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.ORCID 0000-0003-0877-2710

Jonathon E MohlComputational Sciences Program, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Eda KoculiDepartment of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.ORCID 0000-0001-9477-555X

Funding

Studies of Ribosome BiogenesisR01GM131062 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI KOCULI, EDA · 2019 to 2023

$1.7M

NIGMS NIH HHS R01 GM131062

6 · The paper itself

Abstract

Ribosomal RNA (rRNA) modification and processing are essential steps in the ribosome assembly. Using Oxford Nanopore direct RNA sequencing, we simultaneously detect and quantify

Indexed as

Escherichia coliRibosome Subunits, Large, BacterialRNA, BacterialRNA, RibosomalEscherichia coli ProteinsRNA MethylationRNA Processing, Post-TranscriptionalRNA, Ribosomal, 23SSequence Analysis, RNAStress, PhysiologicalEscherichia coli ProteinsRNA, BacterialRNA, RibosomalRNA, Ribosomal, 23S

Identifiers

PMID41891765

DOI10.1021/acs.biochem.6c00004

PMCPMC13431456

What Socratic holds

Textmetadata

LicenceTDM

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.