Evidence map›Paper›PMID 41892001›Full record

ArticleDiseases (Basel, Switzerland)2026

Association of Fetal Growth Retardation with Postnatal Osteoprotegerin Concentrations and Aortic Intima-Media Thickness.

Ageliki A Karatza, Eirini Kostopoulou, Sotirios Fouzas, Nikolaos Antonakopoulos, Xenophon Sinopidis, Dimitra Kritikou, Alexandra Efthymiadou, Gabriel Dimitriou, Dionysios Chrysis

Abstract read
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In one paragraph

Article in Diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ageliki A KaratzaDepartment of Paediatrics, University of Patras Medical School, 26504 Patras, Greece.
Eirini KostopoulouDepartment of Paediatrics, University of Patras Medical School, 26504 Patras, Greece.ORCID 0000-0002-7051-7537
Sotirios FouzasDepartment of Paediatrics, University of Patras Medical School, 26504 Patras, Greece.ORCID 0000-0001-7617-9076
Nikolaos AntonakopoulosFetomaternal Unit, Department of Obstetrics and Gynaecology, University of Patras Medical School, 26504 Patras, Greece.
Xenophon SinopidisDepartment of Paediatrics, University of Patras Medical School, 26504 Patras, Greece.ORCID 0000-0002-0878-0668
Dimitra KritikouDepartment of Paediatrics, University of Patras Medical School, 26504 Patras, Greece.
Alexandra EfthymiadouDepartment of Paediatrics, University of Patras Medical School, 26504 Patras, Greece.
Gabriel DimitriouDepartment of Paediatrics, University of Patras Medical School, 26504 Patras, Greece.ORCID 0000-0001-7929-1573
Dionysios ChrysisDepartment of Paediatrics, University of Patras Medical School, 26504 Patras, Greece.ORCID 0000-0002-7779-9207

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFetal Growth Retardation (FGR) is considered a risk factor for atherosclerosis and coronary artery disease in adulthood. Osteoprotegerin (OPG), a member of the tumor necrosis factor receptor superfamily, is reported to be elevated in atherosclerosis.

objectivesIn this case-control study, we investigated whether FGR affects postnatal OPG serum concentrations and the possible association between OPG levels and aortic intima-media thickness (aIMT), an index of preclinical atherosclerosis.

methodsWe studied 30 infants with FGR and 30 appropriate for gestational age (AGA) infants matched for gestational age and sex. Quantitative determination of plasma OPG was performed via enzyme immunoassay on the second (DOL2) and fifth (DOL5) day of life. aIMT was measured in the distal abdominal aorta and adjusted for aortic lumen diameter.

resultsInfants with FGR had significantly higher OPG levels on both DOL2 and DOL5 as compared to controls (DOL2: 5.4 ± 1.0 pmol/L vs. 4.6 ± 1.0 pmol/L,

conclusionsWe report significantly increased concentrations of OPG in infants with FGR and a positive correlation with aIMT. Follow-up studies with repeat OPG and aIMT measurements may be indicated to evaluate whether these findings represent a permanent effect of FGR on the offspring.

Indexed as

aortic intima–media thicknesscardiovascular diseasedevelopmental origins of health and disease (DOHAD)fetal growth retardation (FGR)infantsosteoprotegerin

Identifiers

PMID41892001
PMCPMC13025314

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.