Evidence map›Paper›PMID 41892006›Full record

ArticleDiseases (Basel, Switzerland)2026

Tear Film Interferometry, Meibography, and Optical Coherence Tomography Angiography for Rosacea.

Matteo Capobianco, Marco Zeppieri, Federico Visalli, Francesco Pellegrini, Leandro Inferrera, Rosa Giglio, Irene Gattazzo, Francesco Cappellani, Fabiana D'Esposito, Caterina Gagliano

Abstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matteo CapobiancoEye Clinic, Catania University, Policlinico G. Rodolico, 95121 Catania, Italy.ORCID 0009-0009-2969-8610
Marco ZeppieriDepartment of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.ORCID 0000-0003-0999-5545
Federico VisalliEye Clinic, Catania University, Policlinico G. Rodolico, 95121 Catania, Italy.ORCID 0009-0005-6710-2460
Francesco PellegriniDepartment of Ophthalmology, ASFO Pordenone Hospital, 33170 Pordenone, Italy.
Leandro InferreraDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy.
Rosa GiglioDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0001-9755-0786
Irene GattazzoDepartment of Ophthalmology, Ospedale Sant'Antonio, Azienda Ospedaliera, 35127 Padova, Italy.ORCID 0000-0003-0069-0171
Francesco CappellaniDepartment of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, 94100 Enna, Italy.ORCID 0009-0007-6807-9455
Fabiana D'EspositoDepartment of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, 94100 Enna, Italy.ORCID 0000-0002-7938-876X
Caterina GaglianoDepartment of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, 94100 Enna, Italy.ORCID 0000-0001-8424-0068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesRosacea is a chronic inflammatory dermatosis that may involve the eye, causing surface and adnexal damage that can precede cutaneous signs. Detecting subclinical ocular changes is clinically important because early ocular surface dysfunction may be missed on routine examination yet progress to corneal complications, allowing earlier preventive management when identified. We prospectively evaluated subclinical ocular alterations in cutaneous rosacea using a combined, fully non-invasive high-tech imaging workflow-tear film interferometry, infrared meibography, and exploratory retinal optical coherence tomography angiography (OCT-A)-including patients without clinically evident ocular involvement.

methodsSixteen patients with cutaneous rosacea (mean age 44.3 ± 11.2 years; 4 males, 12 females) were enrolled and divided into: Group 1-rosacea with clinically evident ocular involvement (

resultsOCT-A showed no significant alterations in superficial or deep retinal plexuses across groups (

conclusionsTear film interferometry and meibography detect early ocular surface impairment in rosacea-even in the absence of clinical signs-while retinal microvasculature appears unaffected. Routine ophthalmologic screening of all rosacea patients could enable prompt treatment of subclinical dysfunction, potentially preventing corneal complications. Retinal OCTA metrics were not significantly different in this small pilot cohort, and these negative findings should be interpreted cautiously pending larger studies.

Indexed as

lipid layer thicknessmeibographyOCT angiographyocular rosacearosaceatear film

Identifiers

PMID41892006
PMCPMC13025564

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.