Molecular Mechanisms of Juvenile Nasopharyngeal Angiofibroma: A Narrative Review.

Xingchen Liu, Junying Hu, Weigang Gan, Feng Liu, Bing Zhong

Abstract readReview

In one paragraph

Review in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xingchen LiuDepartment of Otolaryngology Head and Neck Surgery, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu 610041, China.

Junying HuDepartment of Otolaryngology Head and Neck Surgery, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu 610041, China.

Weigang GanDepartment of Otolaryngology Head and Neck Surgery, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu 610041, China.

Feng LiuDepartment of Otolaryngology Head and Neck Surgery, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu 610041, China.

Bing ZhongDepartment of Otolaryngology Head and Neck Surgery, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu 610041, China.

Funding

Feng Liu sci foundation

6 · The paper itself

Abstract

Juvenile nasopharyngeal angiofibroma (JNA), a rare vascular tumor in adolescent males, involves dysregulated angiogenesis and hormonal interplay. Key molecular drivers include HIF-1α, VEGF, bFGF, and β-catenin, promoting tumor growth via pathways like Wnt/β-catenin and Ras signaling. Androgens and estrogen modulate progression, though mechanisms remain debated. Targeted therapies reduce tumor proliferation and vascularity in preclinical studies, yet clinical translation is hindered by drug resistance and inconsistent biomarker expression. Hormonal and MMP-targeted approaches also show potential but require validation. This review consolidates JNA's molecular landscape, emphasizing the need for personalized strategies, biomarker refinement, and combination therapies to improve therapeutic outcomes for this challenging tumor.

Indexed as

AngiofibromaNasopharyngeal NeoplasmsHumansMalejuvenile nasopharyngeal angiofibromamolecular markerstargeted therapy

Identifiers

PMID41892175

DOI10.3390/curroncol33030147

PMCPMC13025281

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.