Evidence map›Paper›PMID 41892253›Full record

ArticleBiology2026

Comparative Effects of Dexamethasone and ASC Secretome in an Ex Vivo Osteoarthritis Co-Culture Model.

Elena Della Morte, Francesca Cadelano, Andrea Pasquini, Luigi Zagra, Alessandro Baj, Chiara Giannasi, Stefania Niada

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elena Della MorteLaboratory of Biotechnological Applications, IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy.ORCID 0000-0003-1361-168X
Francesca CadelanoLaboratory of Biotechnological Applications, IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy.ORCID 0000-0002-1658-8932
Andrea PasquiniHip Department, IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy.ORCID 0009-0002-4550-5670
Luigi ZagraHip Department, IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy.ORCID 0000-0001-6687-2029
Alessandro BajLaboratory of Biotechnological Applications, IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy.ORCID 0000-0002-1543-1247
Chiara GiannasiLaboratory of Biotechnological Applications, IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy.ORCID 0000-0002-7186-7432
Stefania NiadaLaboratory of Biotechnological Applications, IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy.ORCID 0000-0003-3655-9968

Funding

Italian ministry of health Ricerca Corrente
6 · The paper itself

Abstract

Osteoarthritis (OA) is a multifactorial disease characterized by inflammation, extracellular matrix remodeling, and joint degeneration, and it still lacks disease-modifying treatments. Here, we applied an ex vivo OA model based on transwell co-cultures of cartilage and synovial membrane explants harvested from OA patients to compare the effects of adipose-derived stem/stromal cell (ASC) conditioned medium (CM) with dexamethasone (DEX), a clinically used corticosteroid. Explants were treated for 48 h with 100 nM DEX, CM derived from 5 × 10

Indexed as

conditioned mediumextracellular vesiclesex vivo co-culture modelimmunomodulationinflammationmatrix metalloproteinasesmesenchymal stromal cellsosteoarthritissecretomesynovium–cartilage cross-talk

Identifiers

PMID41892253
PMCPMC13023977

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.