Evidence map›Paper›PMID 41892866›Full record

ArticleMedical sciences (Basel, Switzerland)2026

Evaluating the Efficacy of CPS, HEART and TIMI Score in Emergency Department Patients with Non-Traumatic Chest Pain: A Pilot Study.

Pietro Pozzessere, Mattia Di Lauro, Francesco Incantalupo, Alessandro Cinquantasei, Stefano Palazzo, Mario Erminio Lepera, Antonella Pistone, Sandra De Matteis, Marco Matteo Ciccone, Vincenzo Brescia and 3 more

Abstract read
In one paragraph

Article in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pietro PozzessereDepartment of Emergency Medicine, University Hospital of Bari, 70124 Bari, Italy.
Mattia Di Lauro"M. Albanesi" Allergy and Immunology Unit, 70124 Bari, Italy.
Francesco IncantalupoDepartment of Emergency Medicine, University Hospital of Bari, 70124 Bari, Italy.
Alessandro Cinquantasei"M. Albanesi" Allergy and Immunology Unit, 70124 Bari, Italy.
Stefano Palazzo"M. Albanesi" Allergy and Immunology Unit, 70124 Bari, Italy.
Mario Erminio LeperaUniversity Cardiologic Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, 70120 Bari, Italy.
Antonella PistoneDepartment of Emergency Medicine, University Hospital of Bari, 70124 Bari, Italy.
Sandra De MatteisDepartment of Emergency Medicine, University Hospital of Bari, 70124 Bari, Italy.
Marco Matteo CicconeUniversity Cardiologic Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, 70120 Bari, Italy.
Vincenzo BresciaClinical Pathology Unit, AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII, 70124 Bari, Italy.
Roberto LoveroClinical Pathology Unit, AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII, 70124 Bari, Italy.
Marcello Albanesi"M. Albanesi" Allergy and Immunology Unit, 70124 Bari, Italy.
Angela Pia CazzollaDepartment of Medicine and Surgery, University LUM 'Giuseppe Degennaro', Casamassima, 70010 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe correct identification of patients presenting with chest pain and the stratification of their risk for major adverse cardiovascular events (MACE) is essential. The aim of this study was to evaluate subjects who came to the ED for chest pain through the chest pain score, the HEART score and the TIMI risk score in order to assess their validity and prognostic accuracy and to compare their performance.

methodsPatients included in the study met the following criteria: age ≥18 years, reported atraumatic chest pain, and consent to participate in the clinical study. Subsequently, the final scores were calculated based on the information collected and a follow-up was performed to assess the occurrence of adverse cardiovascular events (MACEs) at 30 days. The MACEs considered were a composite endpoint of STEMI or NSTEMI myocardial infarction, positive coronary angiography for critical lesions, percutaneous coronary angioplasty, coronary artery bypass grafting, and death.

resultsA total of 102 patients were included in the study sample, divided into 76 patients who did not develop MACEs and 26 patients who experienced MACEs. The AUC values of the ROC curves of the chest pain score, HEART score and TIMI risk score were 0.8312, 0.9757 and 0.9378 respectively.

conclusionsAll three scores examined were considered excellent tools to predict the onset of MACEs in patients with chest pain at different points of clinical management, although the HEART score outperformed both the chest pain score and the TIMI risk score in terms of prognostic accuracy.

Indexed as

Chest PainEmergency Service, HospitalAgedCoronary AngiographyFemaleHumansMaleMiddle AgedPilot ProjectsPrognosisRisk AssessmentROC CurveAcute Coronary Syndrome (ACS)cardiovascular riskchest painChest Pain Score (CPS)clinical scoresemergency departmentHEART scorerisk stratificationTIMI risk Scoretriage

Identifiers

PMID41892866
PMCPMC13027872

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.