Evidence map›Paper›PMID 41892991›Full record

ArticleMuscles (Basel, Switzerland)2026

Phosphodiesterase 4 (PDE 4) Inhibition Reduces Ischemia-Reperfusion-Induced Leucocyte Infiltration, Apoptosis and Mitochondrial Fission Markers in Mice Skeletal Muscles Four Hours After Ischemia Onset.

Anne-Laure Charles, Liliane Tetsi, Giulia Quiring, Cindy Barnig, Margherita Giannini, Alain Meyer, Anne Lejay, Claire Lugnier, Bernard Geny

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscles (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne-Laure CharlesUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.ORCID 0000-0003-3557-2642
Liliane TetsiUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.
Giulia QuiringUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.
Cindy BarnigUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.ORCID 0000-0001-8890-3236
Margherita GianniniUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.
Alain MeyerUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.
Anne LejayUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.
Claire LugnierUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.ORCID 0000-0002-0850-1331
Bernard GenyUR 3072, "Mitochondria, Oxidative Stress and Muscle Plasticity", Biomedicine Research Center of Strasbourg (CRBS), Faculty of Medicine, University of Strasbourg, 67081 Strasbourg, France.ORCID 0000-0002-5824-6359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia-reperfusion (IR) settings, but whether PDE 4 inhibition protects skeletal muscle against IR deleterious effects is unknown. We therefore performed limb IR (two hours each) in twenty-one male Swiss mice (12-16-week-old) treated or not with Rolipram (1 mg/kg i.p. 30 min before ischemia and 5 min before reperfusion). The muscles were analyzed 4 h after the onset of ischemia. IR significantly increased leucocyte infiltration (93.13 ± 6.886 vs. 150.1 ± 18.38 cells/mg of muscle,

Indexed as

apoptosiscyclic nucleotide phosphodiesterase (PDE) inhibitionfissioninflammationischemia–reperfusionleucocytesmitochondriamuscleoxidative stressPDE 4

Identifiers

PMID41892991
PMCPMC13028969

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.