Evidence map›Paper›PMID 41893182›Full record

ArticleJournal of functional biomaterials2026

Standardized Photobiomodulation Dosimetry Targeting the Base of Calvarial Critical-Sized Defects for Bone Regeneration: A Preclinical RCT Comparing Flattop vs. Gaussian Beam Profiles, with or Without Bio-Oss

Reem Hanna, Wayne Selting, Vincenzo Cuteri, Giacomo Rossi, Alessandro Bosco, Laura Emionite, Michele Cilli, Emanuela Marcenaro, Federico Rebaudi, Marco Greppi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Reem HannaDepartment of Restorative Dental Sciences, Eastman Dental Institute, Medical Faculty, University College London (UCL), 21 University Street, London WC1E 6DE, UK.ORCID 0000-0003-2882-2156
Wayne SeltingDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132 Genoa, Italy.
Vincenzo CuteriSchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione, 93/95, Matelica, 62024 Camerino, Italy.ORCID 0000-0001-9536-3506
Giacomo RossiSchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione, 93/95, Matelica, 62024 Camerino, Italy.ORCID 0000-0001-8617-5984
Alessandro BoscoBosco Ottico S.r.l, Via Ceradelli, 10, Castel Rozzone, 24040 Bergamo, Italy.
Laura EmioniteAnimal Facility, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
Michele CilliAnimal Facility, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
Emanuela MarcenaroDepartment of Experimental Medicine (DIMES), University of Genoa, Viale Benedetto XV, 1, 16132 Genoa, Italy.ORCID 0000-0003-4103-7566
Federico RebaudiDepartment of Experimental Medicine (DIMES), University of Genoa, Viale Benedetto XV, 1, 16132 Genoa, Italy.
Marco GreppiDepartment of Experimental Medicine (DIMES), University of Genoa, Viale Benedetto XV, 1, 16132 Genoa, Italy.
Stefano BenedicentiDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132 Genoa, Italy.

Funding

University of Genoa 100010-2017-SB-MASTER_001
6 · The paper itself

Abstract

Photobiomodulation (PBM) has shown promising potential to enhance bone regeneration; however, its optimal delivery parameters and interactions with osteoconductive scaffolds remain insufficiently defined. This preclinical study is the first to incorporate a pilot dosimetry evaluation to standardize 980-nm PBM delivery and ensure that effective irradiance reached the target surface of critical-size calvarial defects in mice. The primary aim was to evaluate the effectiveness of this novel 980-nm PBM protocol delivered using either flat-top (FT) or standard Gaussian (ST) handpieces in enhancing bone regeneration in critical-size defects (CSDs), both with and without Bio-Oss

Indexed as

980 nmBio-Oss®bone regenerationcalvarial defectflattop beam profilegaussian profilehistologyimmunohistochemistryosteogenesisphotobiomodulation

Identifiers

PMID41893182
PMCPMC13028131

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.