Evidence map›Paper›PMID 41893304›Full record

ArticleMetabolites2026

Integrating Transcriptomics and 3D Spheroid Models Reveals Microenvironment-Dependent Purinergic Modulation in Hepatocellular Carcinoma.

Arieli Cruz de Sousa, Augusto Ferreira Weber, Vinícius Klain, Juliete Nathali Scholl, Jéssica Marques Obelar Ramos, Natália Baltazar do Nascimento, Maria Luiza Giehl, Renata Kruger Martins, João Vitor Heres, Camila Kehl Dias and 3 more

Abstract read
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Arieli Cruz de SousaLaboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
Augusto Ferreira WeberLaboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
Vinícius KlainOne Health Research Group, Biotechnology Center, Graduate Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.ORCID 0000-0002-6048-5324
Juliete Nathali SchollLaboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.ORCID 0000-0002-9509-2010
Jéssica Marques Obelar RamosLaboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.ORCID 0000-0003-1213-4519
Natália Baltazar do NascimentoGraduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.ORCID 0000-0001-6820-7452
Maria Luiza GiehlLaboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
Renata Kruger MartinsLaboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
João Vitor HeresLaboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
Camila Kehl DiasLaboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
Renata MarschnerLaboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
Fabrício FigueiróLaboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.ORCID 0000-0003-0899-6407
Fátima Costa Rodrigues GumaLaboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.

Funding

National Council for Scientific and Technological Development 163748/2021-7National Council for Scientific and Technological Development 311540/2025-2
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

doxazosindrug resistancehepatic stellate cellsNT5Esorafenib

Identifiers

PMID41893304
PMCPMC13027536

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.