Evidence map›Paper›PMID 41893641›Full record

ArticleVeterinary sciences2026

Evaluating the Antioxidant Potential of Coumestrol in the Treatment of Tripterygium Glycoside-Induced Oligospermia in Rats and Its Potential Mechanisms.

Yongzheng Liu, Sikai Chen, Kang An, Long Chen, God'spower Bello-Onaghise, Yu Zhang, Shunda Li, Mo Chen, Haoran Wang, Qianwei Qu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongzheng LiuCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.
Sikai ChenCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.
Kang AnCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.
Long ChenCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.
God'spower Bello-OnaghiseCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.
Yu ZhangCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.
Shunda LiCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.
Mo ChenState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Haoran WangDepartment of Clinical Medicine, School of Clinical Medicine, Southern Medical University, 1023 Shatainan Road, Guangzhou 510515, China.
Qianwei QuCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.
Yanhua LiCollege of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang, Harbin 150030, China.ORCID 0000-0002-3645-7024

Funding

China Agriculture Research System of MOF and MARA CARS-35National Key Research and Development Program of China 2023YFD1800903-2National Natural Science Foundation of China U24A20452National Nature Science Foundation of China 32503099
6 · The paper itself

Abstract

Tripterygium glycoside (TG) is known to disrupt the oxidative balance in bio-systems, inducing oxidative stress-mediated toxic effects on testicular tissue. This study aimed to explore the therapeutic potential of coumestrol (COU) against these adverse effects. Sixty-four male Sprague-Dawley rats were randomized into control and Tripterygium glycoside (TG) groups for four weeks. Following initial intervention, eight rats per group were sacrificed to verify the establishment of the oligospermia model and hormonal dysfunction. The remaining rats were subdivided into five therapeutic subgroups, TG, TG + L-carnitine, and three COU dosage groups (low, medium, and high) to evaluate potential protective effects. The present study comprehensively analyzed its impacts on testicular histomorphology, circulating testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, and redox balance status, as well as a suite of serum biochemical and physiological biomarkers. Our results revealed that TG induced oligospermia in rats, causing significant testicular oxidative stress characterized by excessive accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA), alongside depleted superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC). Conversely, COU treatment effectively mitigated these impairments by significantly downregulating ROS and MDA levels while restoring SOD activity and T-AOC.

Indexed as

antioxidantcoumestrolnetwork pharmacologyoligospermiaoxidative stresstripterygium glucosides

Identifiers

PMID41893641
PMCPMC13030545

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.