ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Intravitreal plungerless injector device (IPLID) for anterior chamber paracentesis: a novel approach to aqueous humor sampling.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the feasibility and preliminary safety of a plungerless intravitreal injector device (IPLID) adapted for aqueous humor aspiration during anterior chamber paracentesis.
methodsIn this proof-of-concept pilot study, ten consecutive eyes undergoing diagnostic anterior chamber paracentesis with the IPLID were prospectively enrolled and compared with a retrospective cohort of ten eyes that underwent conventional syringe-based aspiration. Procedures were performed under slit-lamp visualization. Primary outcomes included feasibility and procedure duration. Secondary outcomes included aspirated volume, intraocular pressure (IOP) changes, wound integrity, patient discomfort (visual analogue scale), and surgeon-reported usability.
resultsAll procedures were successfully completed without intraoperative complications. The device achieved consistent aqueous humor aspiration (48 ± 5 µL) compared with greater variability using conventional methods (59 ± 17 µL). No anterior chamber instability or hypotony occurred. Wounds were self-sealing in all cases, whereas two control cases required bandage contact lenses. Procedure time was shorter and patient discomfort lower with the IPLID (p < 0.01). No adverse events were observed during one-week follow-up.
conclusionsThe plungerless intravitreal injector device appears to be a feasible and safe alternative for anterior chamber paracentesis, enabling controlled and reproducible aqueous humor sampling with improved procedural consistency and patient comfort. Larger prospective studies are warranted to confirm these findings and assess long-term safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.