ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Kidney function decline in working-age adults with cancer diagnosis: A study utilizing claims and health checkup data.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with cancer have an elevated risk of chronic kidney disease (CKD); however, long-term alterations in kidney function among working-age individuals remain underexplored. This study aimed to evaluate differences in the rate of kidney function decline between working-age patients with cancer who received anticancer drug treatment and individuals without a history of cancer.
methodsThis retrospective cohort study used data from the Panasonic Health Insurance Organization (2017-2021). The cancer patient (CP) and non-cancer patient (NCP) groups were defined based on cancer diagnosis and anticancer drug treatment, respectively. Propensity score matching aligned demographics and health factors. Standardized and individualized eGFR changes from the year before diagnosis (Year F) to F + 4 were evaluated across age groups (≤ 50 and ≥ 51 years).
resultsEach group comprised 395 matched individuals. The CP group demonstrated significant decreases in both standardized and individualized eGFR by F + 4 (p = 0.007 and p < 0.001, respectively), whereas the NCP group showed no significant decline. The decline was particularly significant in CP ≤ 50 years (p < 0.001) but not in those ≥ 51 years. Linear mixed-effects models confirmed a significantly larger annual decline in individualized eGFR in the CP group, particularly among younger individuals.
conclusionsWorking-age patients with cancer during active treatment or early follow-up, particularly those aged ≤ 50 years, face a significantly higher risk of impaired kidney function than individuals without a history of cancer. These findings highlight the need for long-term kidney monitoring and protective strategies, especially among younger patients with cancer, to mitigate CKD progression and preserve quality of life and employment outcomes.
Indexed as
Identifiers
41893933What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.