Evidence map›Paper›PMID 41894060›Full record

ArticleNeurosurgical review2026

Neutrophil-to-lymphocyte ratio and the risk of cerebrospinal fluid diversion after posterior fossa tumor resection in pediatrics.

Weitao Zhong, Siyuan Lv, Guanqiao Chen, Weisong Li, Zelin Li, Qiang Wang, Wangming Zhang

Abstract read
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In one paragraph

Article in Neurosurgical review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Weitao ZhongNeurosurgery Center, Department of Pediatric Neurosurgery, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The National Key Clinical Specialty, Ministry of Education, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Siyuan LvNeurosurgery Center, Department of Pediatric Neurosurgery, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The National Key Clinical Specialty, Ministry of Education, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Guanqiao ChenDepartment of Gynecologic Oncology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, Hubei, China.
Weisong LiNeurosurgery Center, Department of Pediatric Neurosurgery, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The National Key Clinical Specialty, Ministry of Education, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Zelin LiNeurosurgery Center, Department of Pediatric Neurosurgery, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The National Key Clinical Specialty, Ministry of Education, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Qiang WangNeurosurgery Center, Department of Pediatric Neurosurgery, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The National Key Clinical Specialty, Ministry of Education, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Wangming ZhangNeurosurgery Center, Department of Pediatric Neurosurgery, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The National Key Clinical Specialty, Ministry of Education, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. wzhang@vip.126.com.

Funding

President Foundation of Zhujiang Hospital, Southern Medical University yzjj2023zb23
6 · The paper itself

Abstract

In this real-world study, we aim to investigate the relationship between NLR and the need for cerebrospinal fluid (CSF) diversion due to permanent hydrocephalus following tumor resection in children with posterior fossa tumors.We analyzed surveillance data on patients under 18 years of age with posterior fossa tumors who were treated at Zhujiang Hospital from January 2011 to September 2023. Patients were divided into two groups based on the initial postoperative NLR value: NLR > 6 and NLR ≤ 6. The relationship between NLR and the need CSF diversion due to permanent hydrocephalus was evaluated using propensity score matching (PSM) and inverse probability weighting (IPW), with adjustments for baseline, preoperative, and postoperative clinical characteristics. A total of 210 patients were included in the study, with 104 in the NLR > 6 group and 106 in the NLR ≤ 6 group. PSM identified 61 matched pairs for analysis. An initial postoperative NLR > 6 was significantly associated with a higher risk of requiring permanent CSF diversion compared to an NLR ≤ 6 (34.4% vs. 13.1%; OR: 3.48, 95% CI: 1.40–8.66, P = 0.006). Furthermore, the results of the IPW analysis were consistent with PSM analysis. The ROC curve analysis demonstrates that the initial postoperative NLR has moderate discriminatory ability in predicting postoperative CSF diversion, with an AUC of 0.70. NLR is a reliable and practical biomarker for stratifying the risk of requiring CSF diversion in patients after posterior fossa tumor resection.

Indexed as

HydrocephalusInfratentorial NeoplasmsLymphocytesNeutrophilsAdolescentChildChild, PreschoolFemaleHumansMaleNeurosurgical ProceduresPostoperative ComplicationsRetrospective StudiesCSF diversionHydrocephalusNeutrophil-to-lymphocyte ratioPosterior fossa tumor

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.