ArticleMolecular biology reports2026
Porphyromonas gingivalis-derived lipopolysaccharide confers chemotherapy resistance and migratory ability on oral cancer cells by activating toll-like receptor 4 signaling pathway.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study examined the Porphyromonas gingivalis-derived lipopolysaccharide (P. g-LPS)-activated-toll-like receptor 4 (TLR4) pathway and its association with resistance to chemotherapy in oral squamous cell carcinoma (OSCC) cells. METHODS AND
resultsThe OSCC cell lines OM-1 and HOC621 were used in this study. Cells were treated with P. g-LPS, TAK-242 as a TLR4 inhibitor, SC75741 as a nuclear factor-kappa B (NF-κB) inhibitor, and AH-6809 as a prostaglandin E2 (PGE2) receptor antagonist. 5-Fluorouracil (5-FU)-induced cytotoxicity was investigated by measuring lactate dehydrogenase that leaked from damaged cells. 5-FU-induced cytotoxicity was attenuated by P. g-LPS in OM-1 cells and HOC621 cells, although this attenuation was relieved by TAK-242, TLR4 siRNA knockdown, or SC75741. P. g-LPS induced phosphorylation and nuclear translocation of NF-kB/p65, and enhanced cyclooxygenase 2 (COX2) expression and PGE2 production in OM-1 cells. 5-FU-induced cytotoxicity was enhanced by AH-6809 in P. g-LPS-treated OM-1 cells. Furthermore, P. g-LPS-promoted cell migration was inhibited by TAK-242 or SC75741 in OM-1 cells. This study also involved an additional experiment focusing on CD44high OSCC cells. 5-FU-induced cytotoxicity was attenuated by P. g-LPS in amoeboid CD44high OM-1 cells when cultured on laminin-332-coated silicone gel. Additionally, P. g-LPS enhanced cofilin-1 dephosphorylation and cell protrusion in amoeboid CD44high OM-1 cells.
conclusionsP. g-LPS is involved in chemotherapy resistance of OM-1 cells by activating the TLR4/NF-kB pathway, which promotes the migratory ability of these cells, and enhancing PGE2 autocrine signaling. P. g-LPS plays a vital role in OSCC cells’ acquisition of a highly malignant phenotype.
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