ArticleMedicine2026
Evaluation of preoperative ACE inhibitors for renal protection in cardiac surgery.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundThere are many causes of acute kidney injury after cardiac surgery. Activation of the renin-angiotensin system is one of the most important mechanisms. In this article, we investigated the effect of angiotensin-converting enzyme (ACE) inhibitor treatment on renal damage in cardiac surgery.
methodsSix hundred twelve patients undergoing cardiac surgery were divided into 2 groups. The patients in group I were 319 patients who used ACE inhibitors before the operation. The patients in Group II consisted of 293 patients who did not use ACE inhibitors. In addition to blood renal parameters and the need for dialysis, length of hospital stay, hospital costs, and readmission rates were evaluated between the 2 groups. In addition to the early-term results, the patients were followed for 2 years for renal destruction.
resultsDialysis was needed in 9 patients in Group I. Hemodialysis was required in 31 of the Group II patients. In addition, the increase in creatinine and blood urea nitrogen levels and the decrease in glomerular filtration rate and creatinine clearance were higher in Group II patients (P <.05). The length of stay in the intensive care unit and hospitalization were statistically significantly higher in Group II patients. In addition, hospital costs and re-hospitalizations were statistically significantly lower in the treatment group.
conclusionThe use of ACE inhibitors before cardiac surgery is effective in preserving renal function in the postoperative period, and these results are important in achieving acceptable and favorable outcomes for patients and the hospital in the postoperative period.
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