ReviewPharmacological reviews2026
Adhesion G protein-coupled receptors.
Abstract readReview
In one paragraph
Review in Pharmacological reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Subtype-Specific Prognostic and Molecular Significance of ADGRD1 in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.Current issues in molecular biology · 2026Article
- CD97/Cells · 2026Review
- The isolated Stachel peptide of the adhesion G protein-coupled receptor ADGRG6 is predominantly disordered with local helical propensity.Biophysical journal · 2026Article
- Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR.Science advances · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
83 authors.
Tobias LangenhanRudolf Schönheimer Institute of Biochemistry, General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany; Comprehensive Cancer Center Central Germany (CCCG), Leipzig, Germany; Faculty of Life Sciences, Institute of Biology, Leipzig University, Leipzig, Germany. Electronic address: tobias.langenhan@gmail.com.
Garret R AndersonDepartment of Molecular, Cell, and Systems Biology, University of California Riverside, Riverside, California.
Demet AraçDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois.
Gabriela AustResearch Laboratories, Department of Orthopedics, Trauma and Plastic Surgery, Medical Faculty, Leipzig University, Leipzig, Germany; Research Laboratories, Department of Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Faculty, Leipzig University, Leipzig, Germany.
Monserrat Avila-ZozayaDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Sofie Morsing BaggerDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Patrick BarthInterfaculty Institute of Bioengineering and Ludwig Institute for Cancer Research Lausanne, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Sandra BerndtRudolf Schönheimer Institute of Biochemistry, Signal Transduction, Medical Faculty, Leipzig University, Leipzig, Germany; Department of Translational Drug Research and Signal Transduction, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany.
Stephen C BlacklowDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.
Beatriz Blanco-RedondoRudolf Schönheimer Institute of Biochemistry, General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Antony A BoucardDepartment of Cell Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Mexico City, Mexico.
James P BridgesDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado; Department of Medicine, Division of Pulmonary Sciences and Critical Care, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Lara-Sophie BrodmerkelRudolf Schönheimer Institute of Biochemistry, General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Kathleen M CaronDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Yin Kwan ChungDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Andrew N DatesDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California.
Virginea de Araujo FariasLaboratory of Molecular Neurooncology, Department of Neurosurgery, O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Daniel Del ToroDepartment of Biomedical Sciences, Institute of Neurosciences (IDIBAPS), University of Barcelona, Barcelona, Spain.
Joseph G DumanDepartment of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas.
Felix B EngelDepartment of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Cardiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
David M FavaraDivision of Structural Studies, MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Oncology, University of Cambridge, Cambridge, UK; Department of Oncology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Caroline J FormstoneDepartment of Clinical, Pharmaceutical and Biological Sciences, University of Hertfordshire, Hatfield, UK.
Chaoyu FuDepartment of Physics and Mechanobiology Institute, National University of Singapore, Singapore, Singapore.
Alain Garcia De Las BayonasDepartment of Molecular and Cell Biology, University of California, Berkeley, California; Howard Hughes Medical Institute, Chevy Chase, Maryland.
Anastasia GeorgiadiInstitute for Diabetes and Cancer, Helmholtz Centre Munich, Neuherberg, Germany; Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany.
David E GloriamDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Randy A HallDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Jörg HamannDepartment of Experimental Immunology, Amsterdam Institute of Immunology and Infectious Diseases, Amsterdam University Medical Center, Amsterdam, the Netherlands; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Peter W HildebrandInstitute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany.
Cheng-Chih HsiaoDepartment of Experimental Immunology, Amsterdam Institute of Immunology and Infectious Diseases, Amsterdam University Medical Center, Amsterdam, the Netherlands; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Bill X HuangLaboratory of Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland.
Jonathan A JavitchDepartments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York.
Hee-Yong KimLaboratory of Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland.
Robert J KittelDepartment of Animal Physiology, Institute of Biology, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.
Gunnar KleinauCharité - Universitätsmedizin Berlin, corporate member of the Freie Univerität Berlin, Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Berlin, Germany.
Richard LeducDepartment of Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Ines LiebscherRudolf Schönheimer Institute of Biochemistry, Signal Transduction, Medical Faculty, Leipzig University, Leipzig, Germany; Department of Translational Drug Research and Signal Transduction, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany.
Hsi-Hsien LinDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Joshua LinnertInstitute of Molecular Physiology (imP), Johannes Gutenberg University Mainz, Mainz, Germany.
Marie-Gabrielle LudwigBiomedical Research, Novartis Pharma AG, Basel, Switzerland.
David C MartinelliUniversity of Connecticut Health, Farmington, Connecticut.
Signe MathiasenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Daniel MatúšDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California.
Mariam MelkumyanLaboratory of Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland.
Ana L Moreno-SalinasDepartment of Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Jan MulderDepartment of Neuroscience, Karolinska Institute, Stockholm, Sweden; Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
Michael A NashDepartment of Chemistry, Institute of Physical Chemistry, University of Basel, Basel, Switzerland; Department of Biosystems Sciences and Engineering, ETH Zurich, Basel, Switzerland.
Kasturi PalDepartment of Biology, Ashoka University, Sonipat, India.
Daniel T PederickDepartment of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Nicole A Perry-HauserCentre for Translational Pharmacology, School of Molecular Biosciences, University of Glasgow, Glasgow, UK.
Xianhua PiaoWeill Institute for Neuroscience, University of California San Francisco, San Francisco, California.
Yu-Qi PingMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Dimitris G PlacantonakisDepartments of Neurosurgery and Cell Biology, NYU Grossman School of Medicine, New York, New York.
Fabian PohlRudolf Schönheimer Institute of Biochemistry, General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Simone PrömelInstitute of Cell Biology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Mette M RosenkildeDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Laurent SabbaghDomain Therapeutics, St-Laurent, Quebec, Canada.
Richard C SandoDepartment of Pharmacology, Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee.
Patrick ScheererCharité - Universitätsmedizin Berlin, corporate member of the Freie Univerität Berlin, Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Berlin, Germany.
Torsten SchönebergRudolf Schönheimer Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany; University of Global Health Equity (UGHE), Kigali, Rwanda.
Elena SeiradakeDepartment of Biochemistry, University of Oxford, Oxford; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford.
Mareike SelchoDepartment of Animal Physiology, Institute of Biology, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.
Florian SeufertInstitute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Leipzig, Germany.
Abhishek K SinghDepartment of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Georgios SkiniotisDepartment of Structural Biology and Center of Excellence for Structural Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Katja SpiessDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Virology and Microbiological Preparedness, Statens Serum Institut, Copenhagen, Denmark.
Norbert SträterInstitute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany.
David StruttSchool of Biosciences, University of Sheffield, Sheffield.
Thomas C SüdhofDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California.
Jinpeng SunAdvanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
Gregory G TallDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.
Doreen ThorRudolf Schönheimer Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.
Douglas G TilleyDepartment of Cardiovascular Sciences, Aging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Kimberley F ToliasDepartment of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas.
Mario VallonInstitute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany.
Erwin G Van MeirLaboratory of Molecular Neurooncology, Department of Neurosurgery, O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Benoit VanhollebekeLaboratory of Neurovascular Signaling, Department of Molecular Biology, ULB Neuroscience Institute, Université libre de Bruxelles, Gosselies, Belgium; WEL Research Institute, Wavre, Belgium.
Giselle R WigginNxera Pharma UK Ltd., Cambridge, UK.
Uwe WolfrumInstitute of Molecular Physiology (imP), Johannes Gutenberg University Mainz, Mainz, Germany; Institute for Quantitative and Computational Biosciences (IQCB), Johannes Gutenberg University Mainz, Mainz, Germany.
Jie YanDepartment of Physics and Mechanobiology Institute, National University of Singapore, Singapore, Singapore.
Nathan A ZaidmanDepartment of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico.
Yimin ZouNeurobiology Section, Biological Sciences Division, University of California, San Diego, La Jolla, California.
Nicole ScholzRudolf Schönheimer Institute of Biochemistry, General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany. Electronic address: scholzlab@gmail.com.
Funding
Notch Signaling in CancerR35CA220340 · NCI · HARVARD MEDICAL SCHOOL · PI BLACKLOW, STEPHEN C. · 2017 to 2023
$7.1MAdrenomedullin Signaling at the Maternal-Fetal InterfaceR01HD060860 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron · 2009 to 2026
$4.8MLatrophilin Function in Synapse FormationR01MH126929 · NIMH · STANFORD UNIVERSITY · PI Thomas C. Sudhof · 2021 to 2026
$4.3MStructure and Function of Tetraspanin ComplexesR01AI172846 · NIAID · HARVARD MEDICAL SCHOOL · PI Stephen C. Blacklow · 2022 to 2026
$4.0MDynamics of Notch SignalingR01CA272484 · NCI · HARVARD MEDICAL SCHOOL · PI Stephen C. Blacklow · 2022 to 2026
$3.3MMechanisms underlying BAI1/ADGRB1 negative regulation of glioblastoma mesenchymal transition and invasion.R01NS117666 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ERWIN G. VAN MEIR · 2021 to 2026
$2.2MStructural and Functional Studies of Cell-Adhesion ReceptorsR35GM148412 · NIGMS · UNIVERSITY OF CHICAGO · PI Demet Arac-Ozkan · 2023 to 2026
$2.2MBAI Adhesion-GPCRs: Key Regulators of Synapse Development and Plasticity in Health and DiseaseR01MH137505 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI Kimberly R Tolias · 2024 to 2026
$2.2MInvestigation of Adhesion GPCR and Ric-8 protein control of heterotrimeric G proteinsR35GM149539 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gregory Gordon Tall · 2023 to 2026
$2.1MSignaling Mechanisms Regulating Rho GTPase-Dependent Synaptic Plasticity Underlying Memory in Health and DiseaseRF1NS062829 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI TOLIAS, KIMBERLY R · 2022 to 2022
$1.9MMolecular and cellular mechanisms of neuronal damage caused by anticancer therapiesR01CA283569 · NCI · BAYLOR COLLEGE OF MEDICINE · PI JOSEPH G DUMAN · 2024 to 2026
$1.4MTargeting MBD2 for medulloblastoma therapyR01NS144449 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ERWIN G. VAN MEIR · 2025 to 2026
$1.1MNCI NIH HHS R01 CA272484NCI NIH HHS R01 CA283569NCI NIH HHS R35 CA220340NIAID NIH HHS R01 AI172846NICHD NIH HHS R01 HD060860NIDDK NIH HHS R00 DK127215NIGMS NIH HHS R35 GM148412NIGMS NIH HHS R35 GM149539NIMH NIH HHS R00 MH117235NIMH NIH HHS R01 MH126929NIMH NIH HHS R01 MH137505NINDS NIH HHS R01 NS117666NINDS NIH HHS R01 NS144449NINDS NIH HHS RF1 NS062829Wellcome Trust 226647/Z/22/Z
Abstract
Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive assessment of the current understanding of aGPCR biology, including a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches, and model systems for their investigation, as well as emerging approaches for their therapeutic targeting. SIGNIFICANCE STATEMENT: Adhesion G protein-coupled receptors are versatile cell-surface proteins that integrate structural, biochemical, and physiological functions, with major roles in health and disease. This review summarizes current knowledge of their molecular features, functions in diverse model systems, and emerging opportunities for therapeutic targeting, providing a comprehensive resource that connects basic biology with translational applications across multiple scientific disciplines.
Indexed as
Receptors, G-Protein-CoupledAnimalsHumansLigandsSignal TransductionLigandsReceptors, G-Protein-Coupled
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.