Evidence map›Paper›PMID 41895258›Full record

ArticleCell systems2026

Systemic rhythmicity of host and bacterial bile acid amidates in the mouse.

Erin R Reilly, Vincent Charron-Lamoureux, Helena Mannochio-Russo, Ethan W Morgan, Nina R Boyle, Imhoi Koo, Emma Coudriet, Fuhua Hao, Ipsita Mohanty, Gary H Perdew and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pan-Metabolomics Repository Mapping of the Carnitine Landscape.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erin R ReillyDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Vincent Charron-LamoureuxSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
Helena Mannochio-RussoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
Ethan W MorganDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Nina R BoyleHuck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Imhoi KooDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Emma CoudrietDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Fuhua HaoDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Ipsita MohantySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
Gary H PerdewDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA; Department of Pharmacology, University of California, San Diego, La Jolla, San Diego, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA; Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA; One Health Microbiome Center, Huck Life Sciences Institute, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: adp117@psu.edu.

Funding

Environmental Chemical Impact on the Host-Microbiome InteractionR35ES035027 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Andrew Patterson · 2023 to 2026
$3.6M
R01: FXR and the Gut Microbiome as Modulators of Non-Alcoholic Fatty Liver DiseaseU01DK119702 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2019 to 2023
$1.5M
Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training ProgramT32DK120509 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW, PERDEW, GARY H. · 2020 to 2024
$781k
NIDDK NIH HHS T32 DK120509NIDDK NIH HHS U01 DK119702NIEHS NIH HHS R35 ES035027
6 · The paper itself

Abstract

Bacterial bile acid amidates (BBAAs) represent an emerging class of host-microbe co-metabolites formed when gut bacteria conjugate bile acids with amino acids beyond taurine and glycine. Although these conjugates have been shown to modulate immune signaling and epithelial integrity, their spatial and temporal distribution across host tissues remains poorly understood. Here, we profiled 690 samples from time-restricted-fed mice, spanning 14 organs, digestive tract contents, and biofluids, to map the temporal dynamics of BBAAs. We identified widespread and tissue-specific oscillations of BBAAs, with the greatest temporal synchronization observed in the ileal contents and progressively diminished rhythmicity in the periphery. Amidates with hydrophilic or hydrophobic side chains remained relatively constant, while aromatic conjugates exhibited the most substantial variation. These findings reveal that BBAAs are temporally and spatially distributed throughout the body, supporting a model in which microbes encode systemic signals through the timing and structure of their metabolites.

Indexed as

BacteriaBile Acids and SaltsAnimalsGastrointestinal MicrobiomeMiceMice, Inbred C57BLBile Acids and Saltsbile acidmass spectrometrymicrobiome

Identifiers

PMID41895258
PMCPMC13035320

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.