ReviewMolecules and cells2026
Molecular continuity between axon guidance and synaptic function.
Review in Molecules and cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The precise assembly of neural circuits is a marvel of cellular engineering, requiring the seamless coordination of long-range axon navigation and short-range synapse formation. Traditionally, these 2 processes were thought to be governed by distinct sets of molecular cues. However, emerging evidence challenges this dichotomy, revealing that proteins canonically associated with mature synaptic transmission are "repurposed" early in development to instruct selective neuronal pairing, including axon guidance and target recognition. In this mini-review, we discuss the molecular versatility of key synaptic proteins, including latrophilins, N-methyl-D-aspartate receptors, cerebellins, neurexins, and other complementary adhesion systems. We highlight how these molecules utilize non-canonical mechanisms, such as ion flux-independent signaling and trans-neuronal adhesion, to couple initial wiring decisions with later synaptic specialization. This functional duality suggests a "molecular continuum" in brain development, offering broader insights into how cells maximize their proteomic toolkit to build complex biological systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.