ArticleAsia Pacific journal of clinical nutrition2026
Myosteatosis mediates the link between specific dietary components and colorectal carcinogenesis: from PPLSS multi-center study.
Article in Asia Pacific journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Impact of oral nutritional supplements on chemotherapy tolerance and overall survival in postoperative colorectal cancer patients undergoing chemotherapy.Asia Pacific journal of clinical nutrition · 2026Trial
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Abstract
BACKGROUND AND
objectivesWe assumed the specific dietary components may impact colorectal carcinogenesis via ectopic fat accumulation. METHODS AND STUDY
designThe multi-center case-control study analyzed CT-derived body composition parameters and dietary intake in 163 colorectal cancer (CRC) patients and 144 non-CRC controls. Ectopic fat distribution was characterized by elevated low-attenuation muscle area (LAMA) and reduced skeletal muscle density (SMD, myosteatosis). We employed logistic regression to assess diet-body composition-CRC associations, mediation analysis to elucidate ectopic fat's role, and random forest modelling to evaluate variable importance in CRC risk prediction.
resultsCRC patients exhibited obvious myosteatosis (68.1 vs. 31.9%, p <0.001), which promoted colorectal carcinogenesis (95%CI: 0.524, 0.935 in men, 95%CI: 0.425, 0.956 in women via reduced SMD). Linear regression revealed diet rich in ani-mal-derived nutrients and carbohydrates increased LAMA (β = 6.31, 95%CI: 0.766, 11.858), but decreased SMD (β = -3.14, 95%CI: -5.173, -1.099) and normal attenuation muscle area (NAMA) in men, while these components elevated visceral adiposity index (VAI) in women (β = 10.8, 95%CI: 1.265, 20.347). Low bean protein consumption decreased NAMA (β = -13.3, 95%CI: -20.812, -5.860) and SMD (β = -2.95, 95%CI: -4.994, -0.908) in men, while increasing VAI (β = 14.6, 95%CI: 0.820, 28.451) in women. Mediation analysis confirmed NAMA (mediated proportion 11.0%, p = 0.026 in men; 7.24%, p = 0.030 in women), LAMA (11.0%, p = 0.040 in men; 14.6%, p = 0.002 in women) and SMD (17.5%, p = 0.004 in men; 15.4%, p = 0.004 in women) mediated the relationship between excessive consumption of animal-derived nutrients and colorectal carcinogenesis.
conclusionsMyosteatosis, an inconspicuous obesity phenotype, plays key role in colorectal carcinogenesis but can be mitigated by partial substitution of red meat with soy protein.
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