ArticleScientific reports2026
Differential miRNA expression during replicative senescence of dental pulp stem cells with potential for forensic age assessment.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Cellular aging is a complex process that complicates biological age estimation in forensic settings due to high variability. This study evaluated whether microRNAs (miRNAs) from human dental pulp stem cells (hDPSCs) can serve as predictive biomarkers of senescence. hDPSCs from four young donors were subjected to replicative exhaustion and stress-induced senescence, with eight miRNAs selected for analysis. Senescence was confirmed by morphological changes, SA-β-Gal activity, and p16^INK4a immunocytochemistry. RT-qPCR quantified miRNA expression, and predictive value was assessed by ROC curves and multivariable models. Senescence induction consistently resulted in distinct morphological and molecular changes, notably upregulation of miR-433-5p, miR-331-5p, miR-221-5p, and miR-328-5p, and downregulation of miR-205-5p, miR-455-5p, and miR-21-5p. While individual miRNAs showed moderate predictive ability, combining multiple miRNAs greatly improved discrimination of senescence. These results support the feasibility of miRNA panels as molecular markers of senescence in hDPSCs and provide a proof-of-concept framework for future studies on cellular aging in a dental matrix of forensic interest.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.