ArticleCommunications medicine2026
Evaluating flow modulating treatment response in intracranial aneurysms using black-blood MRI in vitro.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundChanges in blood flow after brain aneurysm treatment are linked to treatment success. While 4D flow magnetic resonance imaging (MRI) can measure these changes, it is sensitive to metal artifacts from implants. Black-blood MRI, less affected by artifacts, may complement 4D flow MRI. We investigated whether changes in black-blood signal reflect reductions in blood flow and could indicate the success of aneurysm treatment.
methodsWe performed 22 flow experiments using 3D printed models of two patient-derived brain aneurysms and two straight vessels. Flow-modulating devices, including flow-diverter stents and intrasaccular devices, were inserted into 15 aneurysm models, while untreated models served as controls. All models were imaged with 4D flow and black-blood MRI on a 3 T clinical system. Numerical flow simulations were also performed. Blood flow velocity and black-blood signal were compared between treated and untreated models using non-parametric statistical tests, and their relationship was evaluated with correlation analysis.
resultsHere we show that the black-blood signal in straight vessels decreases with increasing velocity (rho = -0.92, p-value = 3.29E-04). Implanted devices reduce blood flow within aneurysms while leaving flow in the parent vessels essentially unchanged. Treated aneurysms exhibit a significant increase in black-blood signal, which correlates inversely with measured velocity (rho = -0.82, p-value = 6.24E-04). The experimentally observed flow reductions match the numerical simulations. Metal artifacts are more pronounced on 4D flow compared to black-blood MRI.
conclusionsBlack-blood MRI may serve as a surrogate marker of blood flow reduction after aneurysm treatment, particularly in cases where metal artifacts limit conventional imaging.
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