ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2026
Keratinocytes: pleiotropic orchestrators of cutaneous immunity and Inflammation - Emerging therapeutic paradigms in dermatological pathologies.
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Lipoic acid synthase modulates psoriasis-like keratinocyte dysfunction in association with oxidative stress, ferroptosis-associated remodeling, and STAT3/NF-κB activation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Tempol Ameliorates Psoriatic Skin Inflammation: Evidence of TLR4/NF-κB/Nrf2 Axis Modulation.Mediators of inflammation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundKeratinocytes, the principal cellular constituents of the epidermis, have transcended their conventional barrier function to emerge as master regulators of cutaneous immune homeostasis and inflammatory pathogenesis. In inflammatory skin diseases such as psoriasis, atopic dermatitis, and systemic lupus erythematosus, keratinocytes orchestrate complex inflammatory cascades through intricate signaling networks. MATERIAL AND
methodsWe conducted a comprehensive literature search in the PubMed database. The search was performed using the following key terms: "Keratinocytes", "Inflammation", "Skin immune diseases", "Immune cell", "Glucocorticoids", "Inflammasomes", "Antioxidants", "Neuropeptide" and "Single-Cell Technologies".
conclusionIn this review, we summarize that keratinocytes play a pivotal role in inflammatory skin pathologies by engaging in bidirectional communication with T lymphocyte subsets, establishing self-amplifying cytokine circuits (e.g., the HMGB1-mediated loop in SLE and the IL-23/Th17 axis in psoriasis), and constitutively producing local glucocorticoid metabolites. Their immunoregulatory capacity is executed through pattern recognition receptor activation and the maintenance of redox balance via antioxidant defense systems such as the SOD2/Nrf2/ARE pathway. Keratinocytes can produce and secrete inflammasomes and neuropeptides, thereby participating in the regulation of inflammation, pruritus, pain and neuro‑immune crosstalk. Furthermore, cutting-edge single-cell transcriptomic profiling has revealed unprecedented keratinocyte heterogeneity and disease-specific subpopulations. In summary, keratinocyte-targeted strategies offer promising interventions to break pathogenic cycles and restore epidermal barrier function.
Indexed as
Identifiers
41896409What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.