Evidence map›Paper›PMID 41896647›Full record

Trial reportNature medicine2026

Time-restricted eating for body weight management in women with polycystic ovary syndrome: a randomized controlled trial.

Sarah Corapi, Mary-Claire Runchey, Jodie Lyons, Maria Alonso de Leon, Vasiliki Pavlou, Shuhao Lin, Mark Ezpeleta, Kelsey Gabel, Lisa Tussing-Humphreys, Vanessa M Oddo and 5 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05629858 (Time Restricted Eating for the Treatment of Polycystic Ovarian Syndrome), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05629858 nacompletednot on this map

Time Restricted Eating for the Treatment of Polycystic Ovarian Syndrome (PCOS)

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2023 to 2024Enrolled76ConditionsPolycystic Ovary Syndrome, Obesity, OverweightArms6-h Time restricted eating (TRE), Calorie restriction (CR), Control
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sarah CorapiDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Mary-Claire RuncheyDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Jodie LyonsDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Maria Alonso de LeonDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Vasiliki PavlouDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9486-9310
Shuhao LinDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Mark EzpeletaDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4613-8892
Lisa Tussing-HumphreysDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Vanessa M OddoDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Shaina J AlexandriaDepartment of Preventive Medicine (Biostatistics), Northwestern University, Chicago, IL, USA.
Julienne SanchezCollege of Medicine (Endocrinology), University of Illinois Chicago, Chicago, IL, USA.
Alaina P VidmarCenter for Endocrinology, Diabetes and Metabolism, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3790-6255
Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA. varady@uic.edu.ORCID http://orcid.org/0000-0002-9279-9934
Sofia CienfuegosDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is an endocrinological disorder characterized by weight-loss resistance. Time-restricted eating (TRE) has become a popular weight-loss tool. However, the efficacy of TRE for weight management in PCOS remains understudied. We evaluated the effectiveness of TRE compared with standard care (daily calorie restriction (CR)) and a no-intervention control in women with PCOS. Seventy-six participants were randomly assigned to one of three groups for 6 months: a 6-hour TRE regimen (all meals consumed between 1 p.m. and 7 p.m., without calorie tracking), a CR plan (25% daily energy restriction) or a control group with no dietary changes. The primary endpoint was percent change in body weight at 6 months. By month 6, body weight significantly decreased in the TRE group (-4.32% (95% CI, -6.20, -2.44), P < 0.01) and the CR group (-4.66% (95% CI, -7.13, -2.19), P < 0.01), relative to controls, with no difference between the TRE and CR groups (0.34% (95% CI, -2.15, 2.83), P = 0.79). No serious adverse events were reported. Our results show that in women with PCOS, TRE induced greater weight loss than the controls and was comparable to that achieved with daily CR. ClinicalTrials.gov registration: NCT05629858 .

Indexed as

Polycystic Ovary SyndromeWeight LossAdultBody WeightCaloric RestrictionFemaleHumansIntermittent FastingYoung Adult

Identifiers

PMID41896647

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.