Evidence map›Paper›PMID 41896913›Full record

ArticleJournal of ovarian research2026

Salidroside represses ovarian cancer progression by targeting FSP1-dependent ferroptosis.

Tingting Hua, Xinchun Wu, Weihui Liu, Zhiying Jia, Yan Ma, Li Li, Xiaoyan Zhu, Muzaipaer Muhetaer, Xuantong Wang, Mayire Tuerxun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tingting Hua *Department of Ultrasound Diagnosis, The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, China.
Xinchun Wu *Medical Imaging Center, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Weihui LiuUltrasound Department, Traditional Chinese Medicine Hospital of Midong District, Urumqi, Xinjiang, China.
Zhiying JiaDepartment of Ultrasound Diagnosis, The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, China.
Yan MaGynecologic Oncology Center, Ovarian Cancer Ward, Third Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Li LiGynecologic Oncology Center, Ovarian Cancer Ward, Third Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Xiaoyan ZhuDepartment of Ultrasound, Shule County People's Hospital, Shule, China.
Muzaipaer MuhetaerDepartment of Ultrasound, Shule County People's Hospital, Shule, China.
Xuantong WangDepartment of Ultrasound, Dushanzi People's Hospital, Dushanzi, China.
Mayire TuerxunDepartment of Ultrasound Diagnosis, Yecheng County People's Hospital, , Kashi Prefecture, Xinjiang Uygur Autonomous Region, China.
Chunxia ZhangDepartment of Medical Ultrasound, Yining City People's Hospital, Yining, 835000, Xinjiang, China.
Weizhen WangDepartment of Ultrasound, Bachu County People's Hospital, Bachu, 843800, Xinjiang, China.
Abudushalamu AbulaiteDepartment of Ultrasound, Shule County People's Hospital, Shule, China.
Fucheng MaDepartment of Ultrasound Diagnosis, The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, China. mafuchengmfc@yeah.net.

Funding

Kashgar Region Science and Technology Plan Project Contract KS2024030
6 · The paper itself

Abstract

Emerging evidence suggests that ferroptosis resistance contributes to the ovarian cancer (OC) carcinogenesis. Here, the study identified a tumour promoting factor FSP1 and investigated the role of Salidroside in OC ferroptosis resistance. In vitro, Salidroside alleviated the ferroptosis resistance of OC cells, and promoted the ferroptosis features. In vivo, Salidroside could inhibit OC growth and stimulate the ferroptosis. Furthermore, Salidroside targeted the FSP1 to reduce FSP1 mRNA level, thereby assisted OC cells to ferroptosis. In public dataset, FSP1 expression was elevated in the OC single-cell transcriptome sequencing. In clinic, the FSP1 level was positively correlated to the O-RADS US grade. Taken together, these findings revealed an important role for Salidroside in OC ferroptosis resistance, which provided novel insight into ultrasonic diagnosis and traditional Chinese medicine in OC.

Indexed as

FerroptosisGlucosidesOvarian NeoplasmsPhenolsAnimalsCell Line, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMiceGlucosidesPhenolsrhodiolosideFerroptosisFSP1O-RADS US.Salidroside

Identifiers

PMID41896913
PMCPMC13137562

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.