Evidence map›Paper›PMID 41897287›Full record

ArticleBiomolecules2026

Genomic Biomarkers and Mutational Landscape of Nonsyndromic Hearing Loss (NSHL) in the Singaporean Population: Clinical Translational Implications.

Che Kang Lim, Mei Shuang Cheng, Gerard Low, Joyce Zhi'en Tang, Jia Hui Ng, Ni Gin Ong, Pei Shan Leem, Su Ann Lim, Jiun Fong Thong, Vanessa Yee Jueen Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Che Kang LimDepartment of Clinical Translation Research, Singapore General Hospital, Singapore 169608, Singapore.ORCID 0000-0002-3361-0900
Mei Shuang ChengDepartment of Clinical Translation Research, Singapore General Hospital, Singapore 169608, Singapore.
Gerard LowDepartment of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore 169608, Singapore.
Joyce Zhi'en TangDepartment of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore 169608, Singapore.ORCID 0000-0002-3271-5305
Jia Hui NgDepartment of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore 169608, Singapore.ORCID 0000-0002-7403-1059
Ni Gin OngDepartment of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore 169608, Singapore.
Pei Shan LeemDepartment of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore 169608, Singapore.ORCID 0000-0001-6197-8879
Su Ann LimDepartment of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore 169608, Singapore.
Jiun Fong ThongDepartment of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore 169608, Singapore.
Vanessa Yee Jueen TanDepartment of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore 169608, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonsyndromic hearing loss (NSHL) is a highly prevalent, genetically heterogeneous condition, yet its molecular basis in the Singaporean population remains underexplored. We performed whole-exome sequencing and integrative bioinformatics analysis in 115 patients with NSHL to define population-specific genetic biomarkers. A molecular diagnosis was achieved in 57% of cases, with 76% of identified variants classified as pathogenic or likely pathogenic and 24% exhibiting high pathogenic potential. Common East Asian NSHL genes, including

Indexed as

DeafnessMutationAdolescentAdultChildChild, PreschoolConnexin 26Exome SequencingFemaleGenetic Association StudiesGenetic MarkersHumansMaleMiddle AgedSingaporeSulfate TransportersConnexin 26Genetic MarkersGJB2 protein, humanSLC26A4 protein, humanSulfate Transportersgenetic biomarkersnonsyndromic hearing lossprecision medicinewhole-exome sequencing

Identifiers

PMID41897287
PMCPMC13024665

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.