Evidence map›Paper›PMID 41897306›Full record

ArticleBiomolecules2026

New Derivatives of 4-Piperidinylphenyl-Linked Thiazoles as VEGFR2 Inhibitors with Potential Cytotoxicity Against Renal Cancer.

Huda K Mahmoud, Thoraya A Farghaly, Hossa F Alshareef, Amani M R Alsaedi, Afaf Y Khormi, Hanan Gaber Abdulwahab, Alaa M Abu Alnjaa, Shadia M Hussein

Abstract read
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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huda K MahmoudDepartment of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt.ORCID 0009-0007-4300-2785
Thoraya A FarghalyDepartment of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt.
Hossa F AlshareefDepartment of Chemistry, Faculty of Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Amani M R AlsaediDepartment of Chemistry, Collage of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-2919-0330
Afaf Y KhormiDepartment of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.
Hanan Gaber AbdulwahabDepartment of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.
Alaa M Abu AlnjaaDepartment of Chemistry, Jamoum University College, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Shadia M HusseinDepartment of Chemical Pathology, Cairo University Hospital, University of Cairo, Giza 12613, Egypt.

Funding

the Deanship of Research and Graduate Studies at King Khalid University RGP1/213/46
6 · The paper itself

Abstract

Herein, a novel series of 4-piperidinylphenyl-linked thiazoles was synthesized as VEGFR2 inhibitors with potential cytotoxic activity against renal cancer. Most of the target compounds inhibited VEGFR2 enzyme at sub-micromolar IC

Indexed as

Antineoplastic AgentsKidney NeoplasmsProtein Kinase InhibitorsThiazolesVascular Endothelial Growth Factor Receptor-2ApoptosisCell Line, TumorCell ProliferationHumansMolecular Docking SimulationStructure-Activity RelationshipSunitinibTyrosine Kinase InhibitorsAntineoplastic AgentsKDR protein, humanProtein Kinase InhibitorsSunitinibThiazolesTyrosine Kinase InhibitorsVascular Endothelial Growth Factor Receptor-2cytotoxicdocking studyrenal cancerthiazoleVEGFR2 inhibitors

Identifiers

PMID41897306
PMCPMC13023839

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.