ArticleBiomolecules2026
Rosmarinic Acid Targets AKR1B1 to Ameliorate Atherosclerosis via Vascular Endothelial Cell Energy Metabolism Regulation.
Taoli Sun, Quanye Luo, Tingting Liu, Xuzhen Lv, Limei Lin, Duanfang Liao, Qinhui Tuo, Wen Chen
Abstract read
In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Taoli SunKey Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Quanye LuoKey Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Tingting LiuKey Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Xuzhen LvKey Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Limei LinKey Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.ORCID 0000-0002-2583-1797 Duanfang LiaoKey Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Qinhui TuoKey Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Wen ChenKey Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China.ORCID 0000-0002-9522-4036 Funding
the Department of Education of Hunan Province 22B0371the National Natural Science Foundation of China 82474115the Natural Science Foundation of Hunan Province 2023JJ40472the Natural Science Foundation of Hunan Province 2025JJ80094
6 · The paper itselfAbstract
Atherosclerosis (AS), a chronic cardiovascular disease, originates from endothelial dysfunction, a process closely linked to cellular energy metabolism. While rosmarinic acid (RA) exhibits protective cardiovascular effects, its precise mechanism against AS remains undefined. This study demonstrates that RA alleviates AS in ApoE
Indexed as
Aldehyde ReductaseAldo-Keto ReductasesAtherosclerosisCinnamatesDepsidesEndothelial CellsEnergy MetabolismAnimalsHumansHuman Umbilical Vein Endothelial CellsMiceRosmarinic AcidSignal TransductionSirtuin 3AKR1B1 protein, humanAldehyde ReductaseAldo-Keto ReductasesCinnamatesDepsidesRosmarinic AcidSirtuin 3AKR1B1atherosclerosisendothelial cellsenergy metabolismrosmarinic acid
Identifiers
PMID41897339
PMCPMC13023468
What Socratic holds
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