In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Bryce JacobsDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.ORCID 0009-0002-5784-1516 Dan IvanovDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.ORCID 0000-0003-1419-6270 Christopher FaulkDepartment of Animal Sciences, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9749-9658 Carmen J BoothDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Raquel Mattos-CanedoDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.
Lucas TianDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.ORCID 0009-0001-5521-1492 Kaitlyn DePietroDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.
Alper UzunDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.ORCID 0000-0001-6489-8591 Wynand P RoosDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-0474-7414 Laurie H SandersDepartments of Neurology and Pathology, Duke University, Durham, NC 27708, USA.
Robert W SobolDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.ORCID 0000-0001-7385-3563 Funding
Research Project 3P01ES028949 · NIEHS · FLORIDA GULF COAST UNIVERSITY · PI Michael Parsons, Robert W Sobol · 2023 to 2023
$918kNCI NIH HHS R01 CA238061NIA NIH HHS R01 AG069740NIEHS NIH HHS P01 ES028949NIEHS NIH HHS R44 ES032522NIEHS NIH HHS U01 ES029518NIH HHS 1P01ES028949-05NIH HHS 1R01AG069740-05NIH HHS 1R01CA238061-05NIH HHS 1R01NS119528-04NIH HHS 1R44ES032522-03NIH HHS 1U01ES029518-05NSF NSF-1841811
6 · The paper itselfAbstract
DNA polymerase beta (Polβ) is a 39 kDa, single polypeptide enzyme that possesses both gap tailoring and nucleotidyl transferase activity and is the key polymerase involved in base excision repair (BER) and the final steps of active gene demethylation. We demonstrated that residues in the mouse Polβ protein, L301 and V303, are critical for Polβ's interaction with the BER scaffolding protein X-ray repair cross-complementing 1 (XRCC1), and mutation of these residues impairs Polβ's ability to bind to XRCC1, negatively impacting BER complex assembly. We developed Polβ
Indexed as
DNA MethylationDNA Polymerase betaAnimalsExcision RepairGene Knock-In TechniquesMiceMice, TransgenicX-ray Repair Cross Complementing Protein 1DNA Polymerase betaX-ray Repair Cross Complementing Protein 1Xrcc1 protein, mousebase excision repairdemethylationDNA polymerase betaXrcc1
Identifiers
PMID41897348
PMCPMC13023549
What Socratic holds
Textmetadata
LicenceCC BY
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