Evidence map›Paper›PMID 41897363›Full record

ArticleBiomolecules2026

High-Dose Ethanol-Induced Immunosuppression Modulates Sex-Specific Disease Outcomes in a Murine Model of Multiple Sclerosis.

Adriana S P Nuncio, Katherine Motovilov, Max Weed, Simali Shah, Sam Bazzi, Esha Idnani, Turner Lime, Daniela Carrizales Sauceda, Regina A Mangieri, Cole Maguire and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adriana S P NuncioDepartment of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-0963-0135
Katherine MotovilovDepartment of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Max WeedDepartment of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0009-0003-9190-3626
Simali ShahDepartment of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Sam BazziDepartment of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-5951-9243
Esha IdnaniDepartment of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Turner LimeDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0009-0008-6687-7303
Daniela Carrizales SaucedaDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0009-0009-4222-4911
Regina A MangieriDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-4499-6183
Cole MaguireDepartment of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-8986-9762
Esther MelamedDepartment of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-5571-3591

Funding

Neurochemical & Behavioral Correlates of ETOH EffectsT32AA007471 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI Kimberly Nixon · 1987 to 2026
$9.2M
Target Validation byAccumbal Plasticity ScreeningU01AA016651 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Regina A. Mangieri · 2006 to 2026
$3.8M
Unraveling the role of the gut microbiome in a rodent model of alcohol use disorderF31AA032720 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI MOTOVILOV, KATHERINE MAY · 2025 to 2025
$40k
Homer Lindsey Bruce & Fred Murphy Jones Endowed Fellowship NANIAAA NIH HHS F31 AA032720NIAAA NIH HHS K08 T26-1616-11NIAAA NIH HHS T32 AA007471NIAAA NIH HHS U01 AA016651NIDA NIH HHS 5T32 DA018926-18The University of Texas at Austin Graduate Continuing Fellowship NA
6 · The paper itself

Abstract

Both epidemiological studies and prior work in animal models suggest that moderate-dose alcohol reduces disease severity across several autoimmune conditions, including multiple sclerosis (MS). However, the mechanisms underlying the potentially beneficial effects of alcohol and how these effects may change with alcohol dose in autoimmunity remain underexplored. In this study, we characterize the effects of chronic, high-dose ethanol consumption in experimental autoimmune encephalomyelitis (EAE), a murine model of MS, by examining EAE disease severity, gut microbial composition, and peripheral cell immunophenotypes. We found that high-dose ethanol-fed males exhibited a significant amelioration in peak EAE disease severity, in association with decreased T cell activation and B cell proportions. Concurrently, we observed proinflammatory shifts in gut microbiota and hepatic lipid accumulation. Our results suggest that high dose ethanol may benefit autoimmune neuroinflammation in EAE through immunosuppressive effects on adaptive immunity, however its toxic systemic effects preclude the use of alcohol as an immunomodulator in MS. Overall, our findings reveal a mechanistic basis for alcohol's beneficial properties in autoimmunity and could inform the development of more targeted disease modifying therapies that recapitulate these benefits without alcohol-associated toxicity.

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalEthanolMultiple SclerosisAnimalsDisease Models, AnimalFemaleGastrointestinal MicrobiomeImmunosuppression TherapyMaleMiceMice, Inbred C57BLT-LymphocytesEthanolalcoholEAEgut microbiomeimmune systemmultiple sclerosissex differences

Identifiers

PMID41897363
PMCPMC13023817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.