Evidence map›Paper›PMID 41897371›Full record

ReviewBiomolecules2026

Preeclampsia Is a Double-Hit Vascular Disorder: The VEGF-HO-1-CSE Axis.

Asif Ahmed, Stephen K Smith, Shakil Ahmad, Keqing Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Asif AhmedMirzyme Therapeutics Limited, Innovation Birmingham Campus, Faraday Wharf, Holt Street, Birmingham B7 4BB, UK.ORCID 0000-0002-8755-8546
Stephen K SmithMirzyme Therapeutics Limited, Innovation Birmingham Campus, Faraday Wharf, Holt Street, Birmingham B7 4BB, UK.
Shakil AhmadAston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, UK.ORCID 0000-0002-9294-0475
Keqing WangAston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, UK.

Funding

Innovate UK 10066967
6 · The paper itself

Abstract

Preeclampsia is a double-hit vascular disorder centred on the VEGF-HO-1-CSE axis. First, excess placental soluble Flt-1 (sFlt-1) neutralises vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), producing an angiogenic deficit that drives endothelial dysfunction, hypertension, proteinuria and end organ injury. Second, the failure of endogenous vascular brakes, heme oxygenase-1 (HO-1/CO) and cystathionine-γ-lyase (CSE)/hydrogen sulfide (H

Indexed as

Cystathionine gamma-LyaseHeme Oxygenase-1Pre-EclampsiaVascular Endothelial Growth Factor AAnimalsEndoglinFemaleHumansHydrogen SulfidePlacentaPlacenta Growth FactorPregnancyVascular Endothelial Growth Factor Receptor-1Cystathionine gamma-LyaseEndoglinHeme Oxygenase-1Hydrogen SulfidePlacenta Growth FactorVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1angiogenic imbalancebiliverdin reductase (BVR)cystathionine γ-lyase (CSE)heme oxygenase-1 (HO-1)hydrogen sulfide (H2S)PlGFpreeclampsiasoluble endoglin (sEng)soluble Flt-1 (sFlt-1)VEGF

Identifiers

PMID41897371
PMCPMC13024034

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.