Evidence map›Paper›PMID 41897372›Full record

ArticleBiomolecules2026

A K

Rafael Sobrano Fais, Simon Gabriel Comerma-Steffensen, Estefano Pinilla, Vladimir V Matchkov, Rita Tostes, Fernando Silva Carneiro, Ulf Simonsen

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rafael Sobrano FaisDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, SP, Brazil.ORCID 0000-0002-4715-7318
Simon Gabriel Comerma-SteffensenDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0001-6516-694X
Estefano PinillaDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-7852-992X
Vladimir V MatchkovDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-3303-1095
Rita TostesDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, SP, Brazil.ORCID 0000-0002-9446-0707
Fernando Silva CarneiroDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, SP, Brazil.
Ulf SimonsenDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-2169-7666

Funding

American Heart Association 24POST1243617Bayer Fund Pulmonary Hypertension Accelerated Bayer Level 3Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/07641-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/11988-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/05638-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/19749-8Novo Nordisk Foundation NFF130C0007739Novo Nordisk Foundation NFF60C0023284Wilhelm Pedersen and Wife's memorial grant
6 · The paper itself

Abstract

Hypertension-induced erectile dysfunction is associated with endothelial dysfunction in the corpus cavernosum. Membrane depolarization activates the NLRP3 inflammasome, with downregulation of endothelial Ca

Indexed as

Endothelin-1Erectile DysfunctionHypertensionIntermediate-Conductance Calcium-Activated Potassium ChannelsNLR Family, Pyrin Domain-Containing 3 ProteinPenisAnimalsInflammasomesInterleukin-1betaMaleMiceMice, Inbred C57BLSmall-Conductance Calcium-Activated Potassium ChannelsEndothelin-1InflammasomesInterleukin-1betaIntermediate-Conductance Calcium-Activated Potassium ChannelsKcnn3 protein, mouseNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSmall-Conductance Calcium-Activated Potassium Channelsarterial hypertensionerectile dysfunctionKCa 2.2/2.3NLRP3 inflammasome

Identifiers

PMID41897372
PMCPMC13023931

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.