ArticleBiomolecules2026
Determination of Pesticide Residue Levels and Serum Paraoxonase 1 Protein Levels in Obese Children: A Case-Control Study.
Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChildhood obesity is becoming an increasingly prevalent global health issue. Pesticides, which pose significant threats to human health and the environment are major risk factors for various diseases, including cancer, obesity, diabetes, autoimmune disorders, and food allergies. Paraoxonase 1 (PON1) is an enzyme found on high-density lipoproteins (HDL) in serum, which hydrolyzes toxic oxon metabolites of organophosphate pesticides, certain carbamates, aromatic and aliphatic lactones, aromatic esters, and oxidized lipids through its calcium-dependent glycoprotein structure. This study aimed to evaluate the relationship between environmental pesticide exposure, childhood obesity, and PON1 levels.
methodsThe study included 58 obese children with a body mass index above the 95th percentile and 43 healthy children of the same age group. Serum PON1 levels were measured using the ELISA method. Levels of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and organophosphorus pesticides (OPPs) in the blood were determined through LC/MS/MS and GC analysis methods.
resultsAccording to ELISA analysis, the PON1 level was significantly lower in the obesity group (102.8 ± 12.49 ng/mL) compared to the control group (134.8 ± 14.29 ng/mL) (
conclusionsOur findings highlight the presence of OPPs and PCBs in the blood of obese children. Although these factors are associated with PON1, further research is needed to evaluate their potential role as risk indicators for obesity.
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