Evidence map›Paper›PMID 41897382›Full record

ArticleBiomolecules2026

Role of Mediterranean Diet Adherence on Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease Patients.

Luca Salomone, Danilo Menichelli, Vittoria Cammisotto, Valentina Castellani, Daniele Pastori, Pasquale Pignatelli, Anna Paola Mitterhofer, Francesca Tinti, Silvia Lai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luca SalomoneNephrology Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0009-0006-1929-3044
Danilo MenichelliDepartment of General Surgery, Surgical Specialties and Anesthesiology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-9467-5903
Vittoria CammisottoDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1966-5945
Valentina CastellaniDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6455-4828
Daniele PastoriDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6357-5213
Pasquale PignatelliDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2265-7455
Anna Paola MitterhoferNephrology Unit, Department of Systems Medicine, Tor Vergata University of Rome, 00133 Rome, Italy.ORCID 0000-0002-0132-386X
Francesca TintiNephrology Unit, Department of Systems Medicine, Tor Vergata University of Rome, 00133 Rome, Italy.ORCID 0000-0001-8867-3979
Silvia LaiNephrology Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-7199-2954

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by progressive kidney enlargement by cyst formation. Endothelial dysfunction significantly contributes to chronic kidney disease (CKD). The Mediterranean diet (Med-diet) may reduce endothelial dysfunction in ADPKD patients, but its effect was not investigated in these patients. Our aim was to assess the relationship between Med-diet adherence and endothelial function biomarkers such as nitric oxide (NO) and endothelin-1 (ET-1). We enrolled ADPKD patients aged 18-70 years with CKD stages G2-G4. Adherence to the Med-diet was evaluated using the PREDIMED questionnaire. NO and ET-1 were evaluated at enrolment. Correlations and associations between these markers and Med-diet adherence were analysed. We enrolled 63 patients with ADPKD (mean age was 50.0 ± 11.8 years, 66.7% were female). A low/intermediate adherence to Med-Diet was assessed in 47 (74.6%) patients. When comparing patients with low/intermediate and high adherence, we found a higher NO and lower ET-1 serum concentration (

Indexed as

Diet, MediterraneanEndothelium, VascularPatient CompliancePolycystic Kidney, Autosomal DominantAdolescentAdultAgedBiomarkersEndothelin-1FemaleHumansMaleMiddle AgedNitric OxideYoung AdultBiomarkersEndothelin-1Nitric OxideADPKDAutosomal Dominant Polycystic Kidney Diseaseendothelial dysfunctionMed-diet

Identifiers

PMID41897382
PMCPMC13024296

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.