ArticleAntioxidants (Basel, Switzerland)2026
Correlation Between Oxidative Stress and Immune Profiles During Immunotherapy in Metastatic Non-Oncogene-Addicted NSCLC Patients.
Mariangela Peruzzi, Lucrezia Tuosto, Alain Gelibter, Cristina Nocella, Angela Leonardo, Valentina Magri, Chiara Cataldi, Saula Checquolo, Ilaria Grazia Zizzari, Daniele Santini and 5 more
Abstract read
In one paragraphArticle in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
Mariangela PeruzziDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0009-0009-7268-5188 Lucrezia TuostoDepartment of Experimental Medicine, Sapienza University of Rome, Regina Elena 324, 00161 Rome, Italy.
Alain GelibterDivision of Medical Oncology, Department of Radiological, Oncological, and Pathological Sciences, "Sapienza" University of Rome, 00185 Rome, Italy.
Cristina NocellaDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Angela LeonardoDivision of Medical Oncology, Department of Radiological, Oncological, and Pathological Sciences, "Sapienza" University of Rome, 00185 Rome, Italy.
Valentina MagriDivision of Medical Oncology, Department of Radiological, Oncological, and Pathological Sciences, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7312-2904 Chiara CataldiDivision of Medical Oncology, Department of Radiological, Oncological, and Pathological Sciences, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-9938-6403 Saula ChecquoloDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0001-5109-8392 Ilaria Grazia ZizzariDepartment of Experimental Medicine, Sapienza University of Rome, Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0001-8263-7248 Daniele SantiniDivision of Medical Oncology, Department of Radiological, Oncological, and Pathological Sciences, "Sapienza" University of Rome, 00185 Rome, Italy.
Roberto CarnevaleDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-6216-9595 Marianna NutiDepartment of Experimental Medicine, Sapienza University of Rome, Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-1809-1003 Aurelia RughettiDepartment of Experimental Medicine, Sapienza University of Rome, Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0002-1863-8251 Giacomo FratiDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0003-2703-3761 Chiara NapoletanoDepartment of Experimental Medicine, Sapienza University of Rome, Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0001-5449-5430 Funding
Sapienza University of Rome RM124190BA8E7D59 and RM123188C3F3E706
6 · The paper itselfAbstract
Oxidative stress is considered one of the cancer hallmarks, influencing tumor initiation, progression, and metastasis. High levels of reactive oxygen species (ROS) impair the effectiveness of the immune response in cancer patients. We examined changes in oxidative stress during immunotherapy, exploring the relationship between the immune system and clinical parameters related to oxidative burden. Several T-cell and myeloid subsets from 79 metastatic non-oncogene-addicted non-small-cell lung cancer (NSCLC) patients were analyzed using flow cytometry. Additionally, 20 cytokines were measured in serum samples, and sNox2-dp levels, an indicator of NOX2 activity, were assessed by ELISA. Seventy-nine healthy donors served as controls. The data showed that cancer patients had higher levels of sNox2-dp compared to healthy donors (
Indexed as
anti-PD1 antibodiesimmunotherapyNOX2NSCLCoxidative stresssNOX2-dp
Identifiers
PMID41897437
PMCPMC13024447
What Socratic holds
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