ArticleAntioxidants (Basel, Switzerland)2026
Oxygen Depletion in FLASH Particle Therapy: Effects of Linear Energy Transfer and Ion Track Structure.
Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ultra-high dose-rate (FLASH) irradiation can transiently deplete oxygen and modulate radical-mediated chemistry in irradiated cells. Cellular antioxidants also contribute to mitigating oxidative damage in a manner dependent on linear energy transfer (LET), as suggested by recent experimental studies. In this work, we employed our multi-track Monte Carlo simulation framework (IONLYS-IRT) to investigate how LET influences transient radiation-induced oxygen depletion (ROD) in a cell-like aqueous environment under FLASH irradiation conditions. FLASH exposures were modeled as single, instantaneous pulses of protons with energies from 300 MeV to 150 keV, corresponding to LET values of ~0.3 to 71 keV/μm. Our simulations revealed a marked decline in oxygen depletion with increasing LET, in agreement with experimental observations. For an intracellular O
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