Evidence map›Paper›PMID 41897753›Full record

ReviewFoods (Basel, Switzerland)2026

Processing-Induced Modifications of Camel Milk Immunoglobulins and Lactoferrin: Implications for Immunocompromised Pediatric Populations and Therapeutic Applications.

Omar A Alhaj, Mohammed O Ibrahim, Nour A Elsahoryi, Ola D Al-Maseimi

Abstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Omar A AlhajDepartment of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.ORCID 0000-0003-0082-3843
Mohammed O IbrahimDepartment of Nutrition and Food Technology, Faculty of Agriculture, Mutah University, Karak 61710, Jordan.ORCID 0000-0001-7319-2056
Nour A ElsahoryiDepartment of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.ORCID 0000-0003-2029-4045
Ola D Al-MaseimiDepartment of Nutrition and Food Science, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt 19117, Jordan.ORCID 0000-0002-3622-8109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunocompromised pediatric populations (children with inborn errors of immunity, HIV infection, and cancer, as well as those undergoing hematopoietic stem-cell transplantation) have severe nutritional challenges, with malnutrition depending on the underlying condition. Camel milk (CM) represents a culturally accessible, high-quality nutritional parameter and functional food naturally enriched with particular immunological components such as heavy-chain antibodies that represent 75% of total immunoglobulins (IGs) and lactoferrin (LF) at a concentration 3-5 times higher than bovine milk (BM). However, there is a critical processing paradox: the thermal treatments required for the microbiological safety of immunosuppressed children who show a 20-fold greater susceptibility to foodborne pathogens degrade the therapeutic bioactive proteins. This comprehensive review provides a systematic evaluation of processing-induced modifications of CM IGs and LF, which involve thermal and non-thermal technologies, and their effects on the molecular structure and biological function. Emerging alternatives such as high-pressure processing (HPP), pulsed electric fields, and strategic fermentation show promising bioactivity retention without compromising safety. Critical knowledge gaps remain in the structure-function relationships of processed CM proteins, necessitating evidence-based optimization strategies to balance microbiological safety with clinically relevant immunomodulatory functions for vulnerable pediatric populations.

Indexed as

camel milkimmunocompromised childrenimmunoglobulinslactoferrinnon-thermal processingpediatric immunodeficiencythermal processing

Identifiers

PMID41897753
PMCPMC13025193

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.