Evidence map›Paper›PMID 41898146›Full record

ReviewBiomedicines2026

Systemic Molecularly Targeted Therapies for Neoadjuvant and Salvage Craniopharyngioma: A Contemporary Narrative Review.

Joseph J Neubecker, Daniel W Griepp, Jeffrey P Turnbull, Joshua Caskey, Shivum Desai, Adam Mansour, Rabia Ahmed, Andrew Beggs, Annie T K Griepp, Heather Heitkotter and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joseph J NeubeckerDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.ORCID 0009-0005-5044-0623
Daniel W GrieppDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.ORCID 0000-0003-3422-4291
Jeffrey P TurnbullDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Joshua CaskeyDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Shivum DesaiDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Adam MansourDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.ORCID 0009-0003-8905-1057
Rabia AhmedDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Andrew BeggsDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Annie T K GrieppDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Heather HeitkotterDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Chad F ClausDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Boyd F RichardsDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.
Prashant S KelkarDivision of Neurosurgery, Henry Ford Health System Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI 48075, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Craniopharyngiomas are rare, histologically benign but locally aggressive intracranial tumors that are associated with substantial visual, endocrine, and hypothalamic morbidity. Advances in molecular characterization have enabled the use of systemic molecularly targeted therapies, particularly in the recurrent or refractory setting, with the goal of limiting further surgical or radiation-related injury to the hypothalamic-pituitary axis. Papillary craniopharyngioma (PCP), defined by near-universal

Indexed as

adamantinomatous craniopharyngiomabevacizumabBRAF V600EIL-6/IL-6 receptor blockadeMEK inhibitorpapillary craniopharyngiomasalvage therapytargeted therapy

Identifiers

PMID41898146
PMCPMC13023772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.