Evidence mapPaperPMID 41898166Full record

ArticleBiomedicines2026

Dialogues in Immunity: The Interplay Between Neutrophils and Macrophages.

Eduardo Anitua, María Troya, Mohammad H Alkhraisat

Abstract readComment
In one paragraph

Article in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eduardo AnituaBTI-Biotechnology Institute, 01007 Vitoria, Spain.ORCID 0000-0002-8386-5303
María TroyaBTI-Biotechnology Institute, 01007 Vitoria, Spain.ORCID 0000-0002-5308-0505
Mohammad H AlkhraisatBTI-Biotechnology Institute, 01007 Vitoria, Spain.ORCID 0000-0003-4422-4527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cooperation between neutrophils and macrophages is essential to innate immunity. Though they share origins, their distinct roles make them complementary in fighting pathogens and regulating inflammation. However, dysregulation can drive chronic inflammation and autoimmune disease, making therapeutic targeting highly challenging. Broad suppression of these cells is risky; instead, precision strategies are needed to modulate their dual roles in promoting and resolving inflammation. Aging further complicates this balance, as impaired neutrophil and macrophage functions-alongside microbiota alterations-contribute to inflammaging and immune dysfunction. Recent advances in technology offer opportunities to explore these interactions in physiologically relevant contexts, paving the way for targeted interventions that restore immune homeostasis without compromising defense mechanisms. This article highlights the need for nuanced approaches to harness neutrophil-macrophage cooperation for therapeutic benefit.

Indexed as

immunitymacrophagesneutrophilsregenerative medicine

Identifiers

PMID41898166
PMCPMC13023959

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.