Evidence mapPaperPMID 41898206Full record

ReviewBiomedicines2026

Arterial Thrombosis in Severe Ulcerative Colitis: A Case-Based Narrative Review of Current Evidence.

Djordje Kralj, Mladen Maksic, Tamara Knezevic Ivanovski, Olga Odanovic, Tijana Maksic, Tijana Gmizic, Zeljko Ivosevic, Dusan Radojevic, Lejla Suljic, Nevena Todorovic and 3 more

Abstract readReview
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Djordje KraljDepartment of Gastroenterology, University Hospital Medical Center Zvezdara, 11000 Belgrade, Serbia.ORCID 0009-0005-9153-2153
Mladen MaksicDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.ORCID 0000-0001-8259-6060
Tamara Knezevic IvanovskiDepartment of Gastroenterology, University Hospital Medical Center Zvezdara, 11000 Belgrade, Serbia.
Olga OdanovicDepartment of Gastroenterology, University Hospital Medical Center Zvezdara, 11000 Belgrade, Serbia.
Tijana MaksicDepartment of Pediatrics, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Tijana GmizicDepartment of Gastroenterology and Hepatology, Clinic of Internal Medicine, University Hospital Medical Center Bežanijska Kosa, Dr Žorža Matea bb, 11000 Belgrade, Serbia.ORCID 0000-0003-4694-5416
Zeljko IvosevicDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Dusan RadojevicDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.ORCID 0009-0000-9700-0215
Lejla SuljicCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Nevena TodorovicDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-9227-1067
Natasa ZdravkovicDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Irfan CorovicCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.ORCID 0009-0006-4675-4344
Srdjan MarkovicDepartment of Gastroenterology, University Hospital Medical Center Zvezdara, 11000 Belgrade, Serbia.ORCID 0000-0001-5009-5704

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease is a recognized risk factor for venous thromboembolism, whereas arterial thrombotic events remain underappreciated despite their substantial clinical consequences. We report a 45-year-old man without significant comorbidities who developed severe ulcerative colitis complicated by diffuse arterial thrombosis, including cerebral infarctions, an ascending aortic mural thrombus, iliac artery thrombosis, and multi-organ infarctions. After stabilization with supportive care and anticoagulation, remission-directed ulcerative colitis therapy and a vascular safety-oriented maintenance strategy were initiated, including vedolizumab and individualized secondary thrombosis prevention. To contextualize this presentation, we integrate current evidence on the epidemiology, clinical phenotypes, underlying mechanisms, and risk factors for arterial thrombosis in inflammatory bowel disease, highlight disease activity as a dominant trigger, and summarize therapy-specific vascular safety considerations across IBD treatment classes.

Indexed as

arterial thrombosisIBDinflammationinflammatory bowel diseaseischemic strokeulcerative colitis

Identifiers

PMID41898206
PMCPMC13023925

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.