Evidence mapPaperPMID 41898291Full record

ReviewBiomedicines2026

Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications.

Josè Starvaggi, Carla Di Chio, Fabiola De Luca, Santo Previti, Maria Zappalà, Roberta Ettari

Abstract readReview
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Josè StarvaggiDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0009-0000-9875-7383
Carla Di ChioDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-3191-3932
Fabiola De LucaDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0009-0000-3431-9421
Santo PrevitiDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-8473-3321
Maria ZappalàDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-8942-797X
Roberta EttariDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-9020-2068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, there has been a growing scientific and clinical interest in nutraceuticals, bioactive compounds derived from natural sources such as plants, fruits and cereals. These substances have gained prominence due to their diverse pharmacological properties, particularly their anti-inflammatory, antioxidant and antitumor activities. In addition, scientific evidence supports their beneficial role in the prevention and management of cardiovascular diseases, which represent the principal focus of the present review. This review provides a comprehensive and detailed analysis of selected nutraceuticals related to the metabolic syndrome, a multifactorial pathological condition characterized by a cluster of metabolic disturbances that collectively increase the risk of developing cardiovascular disease and type 2 diabetes. The metabolic syndrome is typically defined by the presence of abdominal obesity, insulin resistance, hypertension and dyslipidemia, which includes elevated plasma triglyceride levels and decreased concentrations of high-density lipoprotein (HDL) cholesterol. Given the global importance and prevalence of metabolic syndrome, identifying new strategies to treat these disorders, such as the use of nutraceuticals, has become a central focus of biomedical research.

Indexed as

cardiovascular diseaseschemopreventionmetabolic syndromenutraceuticals

Identifiers

PMID41898291
PMCPMC13024294

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.