Evidence map›Paper›PMID 41898370›Full record

ReviewBiomedicines2026

Targeted Interference with USF2 Binding to the SERPINE1 Proximal Promoter E-Box in Dual Mutant p53

Stephen P Higgins, Ralf-Peter Czekay, Craig E Higgins, Paul J Higgins

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stephen P HigginsDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA.
Ralf-Peter CzekayDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA.
Craig E HigginsDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA.
Paul J HigginsDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA.ORCID 0000-0001-5208-1197

Funding

MATRIX MEDIATORS OF WOUND HEALINGR01GM057242 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI HIGGINS, PAUL J. · 1998 to 2010
$3.2M
American Heart Association 14PRE18170012Butler Family Foundation no numberFriedman Family Cancer Fund no numberGraver Family Endowed Fund for Cancer Research no numberNIH HHS R01 GM057242
6 · The paper itself

Abstract

The SERPINE1 gene encodes the serine protease inhibitor plasminogen activator inhibitor type-1 (PAI-1), a major negative regulator of the plasmin-dependent pericellular proteolytic cascade and a crucial determinant in the program of stromal remodeling. Recent omics approaches confirmed that high tumor SERPINE1 levels are prognostic for poor disease outcomes and shorter disease-free survival in various malignancies. Kinetic analysis of biomarkers of cell cycle transit in growth-synchronized p53 dual mutant human keratinocytes confirmed that PAI-1 transcription occurred early after growth activation of quiescent (G

Indexed as

cell cycledecoyE boxgrowth controlHaCaT cells human keratinocytesp53SERPINE1transcriptionUSF1USF2

Identifiers

PMID41898370
PMCPMC13024194

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.