ArticleInternational journal of molecular sciences2026
Synthesis of 2-Aryl-4-aminoquinazolines: Design, Molecular Docking, and In Vitro Assessment of Antibacterial and Cytotoxic Potential.
Felipe Verdugo, Capucine Braillon, Sana Mahjoub, Alejandro Castro-Alvarez, Régine Janel-Bintz, Pierre Fechter, Pascal Villa, Claudio A Jiménez, Diego A Donoso-Ruiz, Marcia Pérez-Fehrmann and 3 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Felipe VerdugoDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Edmundo Larenas 129, Concepción 4070371, Chile.ORCID 0000-0002-2466-5643 Capucine BraillonCNRS, UMR 7242, Biotechnologie et Signalisation Cellulaire, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, Université de Strasbourg, 67400 Illkirch-Graffenstaden, France.
Sana MahjoubCNRS, UMR 7242, Biotechnologie et Signalisation Cellulaire, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, Université de Strasbourg, 67400 Illkirch-Graffenstaden, France.
Alejandro Castro-AlvarezDepartamento de Ciencias Preclínicas, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile.ORCID 0000-0001-8360-8027 Régine Janel-BintzCNRS, UMR 7242, Biotechnologie et Signalisation Cellulaire, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, Université de Strasbourg, 67400 Illkirch-Graffenstaden, France.ORCID 0000-0002-6682-8551 Pierre FechterCNRS, UMR 7242, Biotechnologie et Signalisation Cellulaire, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, Université de Strasbourg, 67400 Illkirch-Graffenstaden, France.ORCID 0000-0001-5912-361X Pascal VillaPCBIS Plateforme de Chimie Biologie Intégrative de Strasbourg, UAR 3286 CNRS/Université de Strasbourg, 67000 Strasbourg, France.ORCID 0000-0003-3466-4852 Claudio A JiménezDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Edmundo Larenas 129, Concepción 4070371, Chile.ORCID 0000-0002-2622-8308 Diego A Donoso-RuizDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Edmundo Larenas 129, Concepción 4070371, Chile.
Marcia Pérez-FehrmannDepartamento de Química, Facultad de Ciencias, Universidad Católica del Norte, Avda. Angamos 0610, Antofagasta 1270709, Chile.ORCID 0000-0001-6887-1396 Víctor KesternichDepartamento de Química, Facultad de Ciencias, Universidad Católica del Norte, Avda. Angamos 0610, Antofagasta 1270709, Chile.ORCID 0000-0001-7455-547X Sergio OrtizUMR 7200 Laboratoire d'Innovation Thérapeutique, CNRS, Strasbourg Drug Discovery and Development Institute (IMS), Université de Strasbourg, 67400 Illkirch-Graffenstaden, France.ORCID 0000-0002-1596-4887 Ronald NelsonDepartamento de Química, Facultad de Ciencias, Universidad Católica del Norte, Avda. Angamos 0610, Antofagasta 1270709, Chile.ORCID 0000-0001-7449-6334 Funding
Commission of the European Community MediHealth Project (grant No. 691158)Vicerrectoría de Investigación y Desarrollo VRID - UdeC 2024001181INI
6 · The paper itselfAbstract
Antimicrobial resistance (AMR) remains a major threat to modern medicine, fueled by the excessive use of antibiotics and the spread of multidrug-resistant pathogens such as methicillin-resistant
Indexed as
Anti-Bacterial AgentsQuinazolinesDrug DesignHep G2 CellsHumansMicrobial Sensitivity TestsMolecular Docking SimulationStaphylococcus aureusStructure-Activity RelationshipTetrahydrofolate Dehydrogenase4-aminoquinazolineAnti-Bacterial AgentsQuinazolinesTetrahydrofolate Dehydrogenaseaminoquinazolinesantibacterial activitymolecular docking studies
Identifiers
PMID41898394
PMCPMC13026357
What Socratic holds
Textmetadata
LicenceCC BY
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