Evidence map›Paper›PMID 41898396›Full record

ReviewInternational journal of molecular sciences2026

Engineering MSC Migration: Roles of Nanoparticles in Activating Migratory Pathways and Functions.

Temuulen Batsaikhan, Hyun Su Lee, Young Joon Seo

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Temuulen BatsaikhanDepartment of Otorhinolaryngology, Wonju College of Medicine Yonsei University, 20 Ilsan-ro, Wonju 26426, Republic of Korea.
Hyun Su LeeDepartment of Otorhinolaryngology, Wonju College of Medicine Yonsei University, 20 Ilsan-ro, Wonju 26426, Republic of Korea.ORCID 0000-0002-5527-0994
Young Joon SeoDepartment of Otorhinolaryngology, Wonju College of Medicine Yonsei University, 20 Ilsan-ro, Wonju 26426, Republic of Korea.

Funding

Commercialization Promotion Agency for R&D Outcomes (COMPA) - funded by the Ministry of Science and ICT (MSIT), Korea. 2710086554
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) hold strong therapeutic potential due to their regenerative, anti-inflammatory, and immunomodulatory properties. A key factor in their effectiveness is the ability to home in to injured sites. However, clinical outcomes are limited by poor homing efficiency, insufficient migration, tracking challenges, and risks of unwanted differentiation. This review explores the molecular mechanisms of MSC homing, particularly the CXCR4/SDF-1 axis and matrix remodeling. We highlight recent advances in using nanoparticles-such as magnetic, silica, and polymer-based systems-to enhance chemokine receptor expression and homing. Future directions include MSC engineering, advanced tracking, and AI-guided delivery strategies to improve therapeutic efficacy.

Indexed as

Cell MovementMesenchymal Stem CellsNanoparticlesAnimalsChemokine CXCL12HumansReceptors, CXCR4Chemokine CXCL12Receptors, CXCR4cell trackinghomingmesenchymal stem cellnanomedicinenanoparticle

Identifiers

PMID41898396
PMCPMC13026932

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.