Early Post-Transplant Changes in Lipoprotein(a), Autotaxin Activity, and Lipid Profile: A Prospective Observational Study of Tacrolimus-Treated Kidney Transplant Recipients in Poland.

Beata Bzoma, Agnieszka Kuchta, Magdalena Dzwonkowska, Daria Kazimierska, Maciej Jankowski, Alicja Dębska-Ślizień

Abstract readObservational Study

In one paragraph

Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Beata BzomaDepartment of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, University Clinical Center in Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, Poland.ORCID 0000-0001-8062-4072

Agnieszka KuchtaDepartment of Clinical Chemistry, University Clinical Center in Gdańsk, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.ORCID 0000-0003-2264-1442

Magdalena DzwonkowskaCentral Clinical Laboratory, University Clinical Center in Gdańsk, Dębinki 7, 80-952 Gdańsk, Poland.

Daria KazimierskaDepartment of Clinical Chemistry, University Clinical Center in Gdańsk, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.

Maciej JankowskiDepartment of Clinical Chemistry, University Clinical Center in Gdańsk, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.ORCID 0000-0003-4540-6955

Alicja Dębska-ŚlizieńDepartment of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, University Clinical Center in Gdańsk, Smoluchowskiego 17, 80-214 Gdańsk, Poland.ORCID 0000-0001-8210-8063

Funding

an educational grant ST 02-100-25 of Gdansk Medical University. ST 02-100-25

6 · The paper itself

Abstract

Kidney transplantation (KTx) corrects many uremia-related metabolic disturbances; however, dyslipidemia remains common in kidney transplant recipients and contributes to persistent cardiovascular risk. Lipoprotein(a) [Lp(a)] is a largely genetically determined proatherogenic lipoprotein that increases in advanced chronic kidney disease (CKD) and may decrease after restoration of renal function. Autotaxin (ATX), an enzyme involved in proinflammatory lipid signaling through the ATX-lysophosphatidic acid axis, has also been implicated in cardiovascular pathology, but its early post-transplant dynamics remain poorly characterized. In addition to quantitative lipid abnormalities, CKD is associated with high-density lipoprotein (HDL) dysfunction and reduced paraoxonase-1 (PON-1) activity; however, data on early post-transplant changes in PON-1 activity are limited. In this prospective observational study, lipid profile parameters, Lp(a) concentration, ATX activity, and PON-1 activity were assessed in 55 Caucasian patients with CKD stage 5, most of whom were dialysis-dependent, before and 2-3 weeks after KTx. All recipients received tacrolimus-based maintenance immunosuppression with corticosteroids and mycophenolate mofetil. After KTx, Lp(a) levels decreased by a median of 21% and ATX activity by 28% (both

Indexed as

Kidney TransplantationLipidsLipoprotein(a)Phosphoric Diester HydrolasesTacrolimusAdultFemaleHumansImmunosuppressive AgentsLysophospholipase DMaleMiddle AgedPolandProspective StudiesImmunosuppressive AgentsLipidsLipoprotein(a)Lysophospholipase DPhosphoric Diester HydrolasesTacrolimusautotaxindyslipidemiakidney transplantationLipoprotein(a)

Identifiers

PMID41898504

DOI10.3390/ijms27062641

PMCPMC13026202

What Socratic holds

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