Evidence map›Paper›PMID 41898515›Full record

ArticleInternational journal of molecular sciences2026

Thrombophilia and Folate Cycle Gene Polymorphisms in the Development of Ischemic Stroke After COVID-19.

Dildora Khaydarova Kadirovna, Nodirjon Kadirovich Khaydarov, Sanobar Nizamovna Rakhmatova, Nilufar Kahhorovna Salomova, Visola Furkatovna Gaffarova, Qunduz Abdullo Qizi Sadulloyeva, Dilshod Izbilloyevich Sadullayev, Mukhammadjon Kahramon Ugli Berdiyev, Bakhodir Igamovich Djumayev, Nodirabegim Akbarovna Shukrulloeva and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dildora Khaydarova KadirovnaDepartment of Neurology and Medical Psychology, Tashkent State Medical University, Farabi Street 2, Tashkent 100109, Uzbekistan.ORCID 0000-0003-0447-0256
Nodirjon Kadirovich KhaydarovDepartment of Neurology and Medical Psychology, Tashkent State Medical University, Farabi Street 2, Tashkent 100109, Uzbekistan.
Sanobar Nizamovna RakhmatovaDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0009-5082-5450
Nilufar Kahhorovna SalomovaDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0001-2060-9142
Visola Furkatovna GaffarovaDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0001-4655-4354
Qunduz Abdullo Qizi SadulloyevaDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0004-5081-4616
Dilshod Izbilloyevich SadullayevDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0001-9973-4113
Mukhammadjon Kahramon Ugli BerdiyevDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0003-3288-6862
Bakhodir Igamovich DjumayevDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0007-9004-1517
Nodirabegim Akbarovna ShukrulloevaDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0009-3156-9906
Ferangiz Shuxratovna MukhamadievaDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0009-0005-9722-4215
Ibodov Bekzod AbdusattotovichDepartment of Neurology and Medical Psychology, Tashkent State Medical University, Farabi Street 2, Tashkent 100109, Uzbekistan.ORCID 0000-0003-2614-2544
Dilbar Tadjievna KhodjievaDepartment of Neurology, Bukhara State Medical Institute, Gijduvan Street, 23, Bukhara 100100, Uzbekistan.ORCID 0000-0002-5883-9533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 not only affects the respiratory system but also increases the risk of cerebrovascular complications, including ischemic stroke. Experimental and clinical data suggest that cytokine dysregulation and polymorphisms of thrombophilia-related genes (MTHFR, MTR, and MTRR) may jointly promote hypercoagulation, endothelial dysfunction, and thromboinflammation, thereby contributing to post-COVID ischemic stroke. This study included 160 patients treated at Zangiota Infectious Diseases Hospitals (2021-2023): 60 patients with ischemic stroke in the acute or post-COVID period (experiment group), 50 COVID-19 patients without ischemic stroke (comparison group), and 50 ischemic stroke patients without COVID-19 (control group). Clinical-neurological and immunological parameters were assessed, and polymorphisms in thrombophilia/folate cycle genes (MTHFR C677T, MTR, and MTRR) were genotyped by PCR/real-time PCR. Statistical analysis included χ

Indexed as

COVID-19Ischemic StrokeMethylenetetrahydrofolate Reductase (NADPH2)ThrombophiliaAgedFemaleFolic AcidGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPolymorphism, GeneticPolymorphism, Single NucleotideSARS-CoV-2Folic AcidMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanCOVID-19folate cycle gene polymorphismshypercoagulation and inflammationischemic strokethrombophilia

Identifiers

PMID41898515
PMCPMC13026903

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.