Evidence map›Paper›PMID 41898593›Full record

ArticleInternational journal of molecular sciences2026

Synergistic Anticancer Activity of Cannabinoids and Terpenes Against Triple-Negative Breast Cancer Resistance.

Mounika Aare, Jassy Mary Lazarte, Aakash Nathani, Breana Boirie, Tamiel N Turley, John A Copland, Mandip Singh

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mounika AareCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.ORCID 0000-0001-7809-4682
Jassy Mary LazarteCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
Aakash NathaniCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.ORCID 0000-0003-1852-6548
Breana BoirieCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
Tamiel N TurleyCancer Biology Department, Mayo Clinic, Jacksonville, FL 32224, USA.
John A CoplandCancer Biology Department, Mayo Clinic, Jacksonville, FL 32224, USA.
Mandip SinghCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.ORCID 0000-0001-9192-8143

Funding

Florida Cancer innovation, Department of Health, Florida 25C25
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) remains highly aggressive and refractory to conventional treatments, underscoring the need for novel combination strategies. Here, we employed 2D and 3D in vitro models, transcriptomic profiling, and in vivo xenograft studies to evaluate the anticancer efficacy of cannabinoids combined with the terpene β-caryophyllene (BC) in resistant TNBC models. Among the tested cannabinoids, cannabichromene (CBC) exhibited the greatest potency, and its combination with BC at sub-toxic concentrations significantly reduced IC

Indexed as

Antineoplastic AgentsCannabinoidsDrug Resistance, NeoplasmTerpenesTriple Negative Breast NeoplasmsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationDrug SynergismFemaleGene Expression Regulation, NeoplasticHumansMDA-MB-231 CellsMiceAntineoplastic AgentsCannabinoidscaryophyllenePolycyclic SesquiterpenesTerpenescannabichromenecombination therapytriple-negative breast cancerβ-caryophyllene

Identifiers

PMID41898593
PMCPMC13026563

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.