Evidence map›Paper›PMID 41898635›Full record

ArticleInternational journal of molecular sciences2026

Endocannabinoid Enhancement via MAGL Inhibition in CDKL5 Deficiency: Selective Cellular Benefits and Domain-Specific Functional Effects in Adult

Manuela Loi, Nicola Mottolese, Giorgio Medici, Feliciana Iannibelli, Nicolò Interino, Giulia Candini, Federica Trebbi, Angelica Marina Bove, Jessica Fiori, Stefania Trazzi and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manuela LoiDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-6179-7610
Nicola MottoleseDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-3066-0945
Giorgio MediciDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.
Feliciana IannibelliDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.
Nicolò InterinoIRCCS Istituto Delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.ORCID 0000-0002-7302-1246
Giulia CandiniDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.ORCID 0009-0005-5029-9594
Federica TrebbiDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.
Angelica Marina BoveDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.
Jessica FioriIRCCS Istituto Delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Stefania TrazziDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-2623-2769
Elisabetta CianiDepartment of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-3130-5168

Funding

CDKL5 Insieme verso la Cura Onlus Ciani_2023
6 · The paper itself

Abstract

CDKL5 Deficiency Disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early disruptions of synaptic maturation and network stability, leading to persistent motor, cognitive, and behavioral impairments. Given the role of the endocannabinoid system in synaptic development, neuroinflammation, and neuronal resilience, we investigated whether the sustained enhancement of endogenous 2-arachidonoylglycerol (2-AG) signaling via monoacylglycerol lipase (MAGL) inhibition could mitigate key pathological features in adult

Indexed as

BenzodioxolesEndocannabinoidsEpileptic SyndromesMonoacylglycerol LipasesPiperidinesProtein Serine-Threonine KinasesSpasms, InfantileAnimalsArachidonic AcidsGlyceridesMaleMiceMice, KnockoutMicrogliaSignal TransductionArachidonic AcidsBenzodioxolesCDKL5 protein, mouseEndocannabinoidsGlyceridesglyceryl 2-arachidonateJZL 184Monoacylglycerol LipasesPiperidinesProtein Serine-Threonine KinasesCDKL5 deficiency disorderendocannabinoid systemMAGL inhibitionmicroglial activation and neuroinflammationsynaptic maturation and neuroprotection

Identifiers

PMID41898635
PMCPMC13026865

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.