Evidence map›Paper›PMID 41898637›Full record

ArticleInternational journal of molecular sciences2026

Design and Biological Profiling of a Drug-like Chloropyridine Diamine as a Dual Antioxidant-Antimicrobial Lead: In Vitro Evaluation and In Silico Multi-Target Studies.

Oussama Merzouki, Elhachmia Ech-Chihbi, Nadia Arrousse, El Houssine Mabrouk, Mohamed Hefnawy, Yasmine Fernine, Manal El-Gendy, Mustapha Taleb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oussama MerzoukiLaboratory of Engineering Electrochemistry, Modeling, and Environment, Department of Chemistry, Faculty of Sciences Dhar Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco.ORCID 0000-0001-5246-6230
Elhachmia Ech-ChihbiLaboratory of Physics and Chemistry of Inorganic and Organic Materials, Higher Normal School, Mohammed V University, Rabat 30050, Morocco.
Nadia ArrousseSchool of Science and Engineering, Al Akhawayn University in Ifrane, Hassan II Avenue, Ifrane 53000, Morocco.
El Houssine MabroukLaboratory of Engineering Electrochemistry, Modeling, and Environment, Department of Chemistry, Faculty of Sciences Dhar Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco.
Mohamed HefnawyDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Yasmine FernineLaboratory of Engineering Electrochemistry, Modeling, and Environment, Department of Chemistry, Faculty of Sciences Dhar Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco.
Manal El-GendyDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Mustapha TalebLaboratory of Engineering Electrochemistry, Modeling, and Environment, Department of Chemistry, Faculty of Sciences Dhar Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco.

Funding

King Saud University ORF-2026-754
6 · The paper itself

Abstract

Bacterial and fungal infections, together with oxidative stress-mediated damage, remain major challenges in human health and in the protection of materials, highlighting the need for new multifunctional molecules that combine antioxidant and antimicrobial properties. In this context, a new chloropyridine-based derivative, N4,N4-bis((6-chloropyridin-3-yl)methyl)-N1,N1-diethylpentane-1,4-diamine (AMZ), was synthesized via a simple, catalyst-free N-alkylation of N1,N1-diethylpentane-1,4-diamine with 2-chloro-4-(chloromethyl)pyridine in acetonitrile at 55 °C, affording a 62% yield. The structure of AMZ was confirmed by melting point determination,

Indexed as

Antifungal AgentsAnti-Infective AgentsAntioxidantsDrug DesignPyridinesAnti-Bacterial AgentsComputer SimulationFungiGram-Negative BacteriaHumansMicrobial Sensitivity TestsMolecular Docking SimulationAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsAntioxidantsPyridinesADMETbiological activitieschloropyridine derivativemolecular dockingsynthesis

Identifiers

PMID41898637
PMCPMC13027077

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.